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调节性T淋巴细胞在移植免疫耐受中的作用研究进展 被引量：1

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摘要 调节性T淋巴细胞（Treg细胞）在正常机体维持T淋巴细胞动态平衡和免疫耐受的机制中扮演重要角色。早在70年代初期，Gerson等就提出正常的胸腺中可能存在一群有免疫抑制能力的T淋巴细胞，但是这个观点被国际免疫学界忽略了近20年。
作者 周晓慧 范慧敏 S.G.Zheng 刘中民
机构地区 同济大学附属东方医院中心实验室 同济大学附属东方医院心胸外科 Department of Medicine
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2008年第9期573-575,共3页 Chinese Journal of Organ Transplantation
基金 上海市国际合作重点项目（1164107049） 美国Wright击者Foundation资助
关键词 T淋巴细胞 移植免疫耐受 调节性 TREG细胞 免疫抑制 免疫学
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献27

  • 1Banham AH. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3 ( + ) regulatory T cells. Trends Immunol, 2006, 27(12):541-544
  • 2Deaglio S, Dwyer KM, Gao W, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med, 2007, 2114 (6) : 1257 -1265.
  • 3Baatar D. Olkhanud P. Sumitomo K. et al. Human peripheral blood T regulatory cells (Tregs), funclionally primed CCR4 + Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL. J Immunol, 2007, 178(8):4891-4900
  • 4Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003, 299(561)9) : 1057-11161.
  • 5Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+ FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood, 2007, 110(8): 2983-2990.
  • 6Du J, Huang C, Zhou B, et al. Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3. J Immunol, 2008, 180(7) :4785-4792.
  • 7Liu W, Putnam AI., Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med, 2006, 2113(7): 1701-1711.
  • 8Seddiki N, Sanmer-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med, 2006, 203(7) : 1693-1700.
  • 9Hartigan-O'Connor DJ, Poon C, Sinclair E. et al. Human CD4 + regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127). allowing consistent identification and sorting of live cells. J Immunol Methods, 2007, 319 (1- 2) : 41-52.
  • 10Zheng SG, Meng L, Wang JH, et al. Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4 + CD25 + cells in the recipient. Int Immunol, 2006, 18(2) :279-289.

同被引文献27

  • 1Sakaguchi S. Naturally arising Foxp3-expressing CD25^+ CD4 + regulatory T cells in immunological tolerance to self and non- self. Nat Immunol, 2005, 6(4) :345-352.
  • 2Newell KA, Phippard D, Turka LA. Regulatory cells and cell signatures in clinical transplantation tolerance. Curr Opin Immunol, 2011, 23(5) :655-659.
  • 3Seddiki N, Santner-Nanan B, Martinson J, et al. Expression of interleukin (IL)-2 and 1L-7 receptors discriminates between human regulatory and activated T cells. J Exp Med, 2006, 203 (7) : 1693-1700.
  • 4Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Treg cells. J Exp Med, 2006, 203 (7):1701- 1711.
  • 5Veronese F, Rotman S, Smith RN, et al. Pathological and clinical correlates of FOXP3 + cells in renal allografts during acute rejection. Am J Transplant, 2007, 7(4):914-922.
  • 6Martin L, Funes de la Vega M, Bocrie O, et al. Detection of Foxp3 + cells on biopsies of kidney transplants with early acute rejection. Transplant Proc, 2007, 39(8):2586-2588.
  • 7Muthukumar T, Dadhania D, Ding R, et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med, 2005, 353(22) :2342-2351.
  • 8Karczewski M, Karczewski J, Kostrzewa A, et al. The role of Foxp3 + regulatory T cells in kidney transplantation. Transplant Proc, 2009, 41 (5) : 1527-1529..
  • 9Akl A, Jones ND, Rogers N, et al. An investigation to assess the potential of CD25highCD4+ T cells to regulate responses to donor alloantlgens in clinically stable renal transplant recipients. Transpl Int, 2008, 21 ( 1 ) : 65-73.
  • 10Iwase H, Kobayashi T, Kodera Y, et al. Clinical significance of regulatory T-cell-related gene expression in peripheral blood after renal transplantation. Transplantation, 2011, 91 (2) : 191-188.

引证文献1

中华器官移植杂志
2008年 第9期

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