sIgA水平对白念珠菌粘附阴道上皮细胞的影响

The Effects of sIgA Level on Adherence of Candida Albicans to Vaginal Epithelial Cells

目的探讨sIgA在念珠菌性阴道炎(CV)发病中的作用。方法采用放射免疫法测定CV组、健康组及带菌组阴道分泌物中sIgA含量,用体外粘附方法测定白念珠菌对阴道上皮细胞(VEC)的粘附能力,观察sIgA水平时白念珠菌粘附VEC的影响。结果CV组sIgA水平明显低于健康组和带菌组(P<0.01);CV组白念珠菌在含sIgA阴道分泌物中粘附能力高于健康组和带菌组(P<0.05);白念珠菌在不含sIgA阴道分泌物中粘附能力各组间差异无显著性意义(P>0.05);白念珠菌临床株和标准株间差异无显著性意义(P>0.05)。结论sIgA对白念珠菌粘附VEC有抑制作用,sIgA水平的降低是CV发病的原因之一,与白念珠菌来源无关。

Objective： To study the role of slgA in the pathogenesis of Candidal Vaginitis（CV）. Methods The sIgA level was determined by radioimmunoassay in CV group,normal group,and bacteria carrying group. Moreover, the adherence of Candida Albicans to vaginal epithelial cells（VEC） was observed by adhesive method in vitro. Results The level of slgA in the CV group was much lower than that of the other two groups （ P 〈 0.01 ）. Also,the adhesion of Candida Albicans in vaginal secretion with sIgA in CV group was higher than that of the other two groups （P 〈0.05）. However,There was no significant difference in adhesion of clinic and standard Candida Albicans in vaginal secretion without slgA among the three groups（P 〉 0.05）. Conclusion sIgA has an inhibitory effect on Candida Albicans adhesion to VEC. Therefore,the low level of sIgA is one of the causes of CV which is independent of the source of Candida Albicans.