早期梅毒血清固定患者淋巴细胞的检测及意义

Detection of Peripheral Blood Lymphocyte Subsets in Early Sero-Resisitant Syphilis

目的探讨细胞免疫与早期梅毒血清固定的关系。方法流式细胞仪检测30例血清阴转和20例血清固定早期梅毒患者的外周血T淋巴细胞亚群及NK淋巴细胞,并与30例健康人对照。结果血清固定组早期梅毒患者CD3,CD4淋巴细胞低于血清转阴组和正常对照组,而CD8淋巴细胞高于这两组,NK淋巴细胞差异无显著性意义;血清阴转组梅毒患者与正常对照组各淋巴细胞亚群和NK细胞差异无显著性意义。结论早期梅毒血清固定患者机体内细胞免疫受到明显抑制及产生免疫不平衡,可能造成了梅毒螺旋体逃脱机体免疫监视而残存,成为引起血清固定的原因之一。

Objective To study of the correlation of cellular immunity and sero - resistance. Methods： T - lymphocyte subsets and NK cells in peripheral blood were measured by flow cytometry （FCM） in 30 early syphilis patients with sero - negative and 20 sero - resistant patients with early syphilis, and 30 healthy subjects were taken as controls. Result： （ 1 ） The sero - re- sistant patients had lower CD3 and CD4 lymphocytes （ P 〈 0. 05 ）, but higher CD8 cells in comparision with the sero - negative and the healthy,and NK cells exhibited no significant difference. （2） It showed no obvious difference of the CD3 ,CD4,CD8 and NK cells levels between the sero - negative and the healthy. Conclusion ： Cellular immunity imbalance and immune suppression can be present in sero - resistant patients with early syphilis, which may help Treponema pallidum to succeed in escaping the im- mune - monitoring of organism and survive. This may be one of the reasons of sero - resistance.