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卵母细胞基因组印迹与辅助生殖技术 被引量：1

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摘要 基因组印迹控制基因的转录与生殖及子代的健康发育密切相关。在原始生殖细胞阶段基因组印迹擦除,而配子的形成阶段印迹重新建立。辅助生殖技术将配子和早期胚胎暴露于体外并进行不同程度的操作,使辅助生殖技术子代印迹基因疾病风险增加。研究印迹基因疾病发病机制及与体外受精的关系,对正确评价该技术并提高辅助生殖子代健康有重要意义。
作者 胡燕军 黄荷凤
机构地区 浙江大学医学院附属妇产科医院生殖内分泌科
出处 《国际生殖健康／计划生育杂志》 CAS 2008年第5期279-282,共4页 Journal of International Reproductive Health/Family Planning
关键词 基因组印迹 辅助生殖技术 DNA甲基化 卵母细胞
分类号 R714.8 [医药卫生—妇产科学]
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参考文献20

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同被引文献36

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  • 3Maher ER, Brueton LA, Bowdin SC, et al. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART) [J].J MedGenet, 2003, 40(1).62-64.
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  • 6Φrstavik KH, Eiklid K, van der Hagen CB, et al. Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmie semen injection[J]. Am J Hum Genet, 2003, 72(1) 218-219.
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国际生殖健康／计划生育杂志
2008年 第5期

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