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转录因子Brn-3a的研究及其与宫颈癌的关系 被引量：1

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摘要 Brn-3a转录因子主要表达于周围神经系统的神经元亚群中,参与神经元的生存和分化相关基因的激活。对Brn-3a的调节包括启动子调节、磷酸化和尤文氏肉瘤蛋白的激活作用。而Brn-3a对神经细胞的调节包括抑制bHLH基因NeuroD4(Math3)和NeuroD1、影响p53的作用、激活α-Internexin启动子、控制感觉神经元中酪氨酸激酶受体A(TrkA)表达及与甾体激素受体共活化物(Src-1)交互作用等。人乳头瘤病毒(HPV)感染是导致宫颈癌的关键因素。已有研究表明Brn-3a与人乳头瘤病毒感染后引起的宫颈细胞癌变有关。但其具体机制及与不同型别人乳头瘤病毒感染的关系等尚有待进一步研究。
作者 肖凤仪 隋龙
机构地区 复旦大学附属妇产科医院
出处 《国际生殖健康／计划生育杂志》 CAS 2008年第5期318-320,共3页 Journal of International Reproductive Health/Family Planning
基金 上海市重点学科建设项目(编号:B-117)
关键词 BRN-3A 宫颈癌 人乳头状瘤病毒
分类号 R737.33 [医药卫生—肿瘤]
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参考文献20

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同被引文献7

  • 1Dhn D, Torkko KC, Shroyer R. Human papillomavirus testing and molecular markers of cervical dysplasia and carcinoma [ J ]. Cancer, 2007, 111(1): 1-14.
  • 2Ripley BJ, Rahman MA, Isenberg DA, et al. Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus crythe- matosus correlates with antibodies to Brn-3 and overexpression of Hsp 90[J]. Amlri Rheum, 2005, 52(4): 1171 -1179.
  • 3Lee H, Leek J, Junq CK, et al. Expression of HPV LI caspid protein in cervical specimens with HPV infection [ J ]. Diaqn Cytopathol, 2008, 36(12): 864-867.
  • 4Callssano M, Faulkes D, Latchman DS. Phosphorylation of the Brn-3atranscription factor is modulated during diferentiation and regulares its functional activity[ J]. Brain Res Mol Brain Res, 2005, 141 ( 1 ) : 10 -18.
  • 5Ndisang D, Fanlkes DJ, Gascoyne D, et al. Differential regulation of diferent human papilloma virus varian ts by the POU family transerip- tion factor Brn-3a[J]. Oncogene, 2006, 25( 1 ) : 51 -60.
  • 6黄雅,冯玉昆,李建军,于璐.Brn-3a、PPAR-γ在宫颈癌及癌前病变中的表达[J].昆明医学院学报,2008,29(1):90-94. 被引量：2
  • 7伊心浩,郑妮,王际亮.宫颈癌患者宫颈脱落细胞HPV、病变组织Brn-3a的表达变化及意义[J].山东医药,2010,50(18):91-92. 被引量：11

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国际生殖健康／计划生育杂志
2008年 第5期

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