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钠-氢交换蛋白的研究进展 被引量：1

Study Progress of Na^+H^+ Exchanger Protein
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摘要 钠-氢交换蛋白质是维持细胞内环境的主要细胞膜蛋白质之一,其主要功能是调节细胞内pH值,使之保持在生理范围之内。细胞内pH值的变化,直接或间接的影响细胞的生长、分裂、增殖、分化和死亡,以及细胞的移动和肿瘤细胞的转移。 Na^＋/H^＋ Exchanger （NHE） protein is one of the main membrane proteins to maintain cellular internal environment： The primary function of NHE is to adjust intra-cellular PH value keeping in normal physical range. The pH value variation in cells has effects on the cells＇ growth, cleavage, generation, differentiation and death directly or indirectly,even on the cells＇ ambulation and tumour cell＇s metastasis.
作者 周慧芬 刁路明 赵红刚
机构地区 武汉大学基础医学院 咸宁学院医学院病理学教研室
出处 《医学综述》 2008年第19期2893-2894,共2页 Medical Recapitulate
关键词 肿瘤 钠-氢交换蛋白 肿瘤治疗 Tumor Na^＋/H^＋ exchanger protein Tumor therapy
分类号 R361.3 [医药卫生—病理学]
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二级参考文献29

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共引文献21

同被引文献31

  • 1Fuster DG,Zhang J,Shi M,et al.Characterization of the sodium/hydrogen exchanger NHA2[J].J Am Soc Nephrol,2008,19(8):1547-1556.
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  • 3Xiang M,Feng M,Muend S,et al.A human Na+/H+antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension[J].Proc Natl Acad Sci USA,2007,104(47):18677-18681.
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  • 6Simonin A,Fuster D.Nedd4-1and beta-arrestin-1are key regulators of Na+/H+exchanger 1 ubiquitylation,endocytosis,and function[J].J Biol Chem,2010,285(49):38293-38303.
  • 7Chen T,Hubbard A,Murtazina R,et al.Myosin VI mediates the movement of NHE3down the microvillus in intestinal epithelial cells[J].J Cell Sci,2014,127(16):3535-3545.
  • 8Hisamitsu T,Ben AY,Nakamura TY,et al.Dimerization is crucial for the function of the Na+/H+exchanger NHE1[J].Biochemistry,2006,45(44):13346-13355.
  • 9Counillon L,Franchi A,Pouyssegur J.A point mutation of the Na+/H+exchanger gene(NHE1)and amplification of the mutated allele confer amiloride resistance upon chronic acidosis[J].Proc Natl Acad Sci USA,1993,90(10):4508-4512.
  • 10Pedersen SF,King SA,Nygaard EB,et al.NHE1inhibition by amiloride-and benzoylguanidine-type compounds.Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity[J].J Biol Chem,2007,282(27):19716-19727.

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医学综述
2008年 第19期

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