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TLR4在肝脏损伤中的作用研究进展 被引量:5

Research Progress in Roles of TLR4 in Liver Damage
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摘要 Toll样受体4(TLR4)是能被某些病原微生物保守分子激活的一种模式识别受体,其配体主要是细菌脂多糖(LPS)。作为细胞膜上LPS的信号传递分子,TLR4通过信号转导参与LPS介导的细胞及组织损伤。LPS介导的TLR4胞内信号转导途径有两条:MyD88依赖途径和非MyD88依赖途径,几种调节蛋白(ST2、IRAK-M、Irak2c、Irak2d和Triad3A)参与信号负调节。TLR4在肝脏各种疾病,包括HBV感染、乙醇性肝损害、肝脏纤维化、肝脏缺血/再灌注损伤中有着重要作用。 Toll-like receptors 4 ( TLR4 ), a kind of pathogen pattern recognition receptors (PRRS) , could be activated by some conserved bacterial and viral components, whose most ligand is lipopolysaccharide (LPS). As a signaling molecule in cell membrane, TLR4 is involved in the damage of cell and tissue by its signal transmission. MyD88-dependeut and MyD88-independent pathway have been found in LPS Mediated signaling. ST2, IRAK-M, Irak2c, Irak2d and Triad3A down-regnlate signal transmission. TLR4 has important roles in various liver disease, including HBV infection, alcoholic liver disease( ALD), Hepatic fibrosis, and hepatic ischemia/reperfusion injury (IR1).
作者 陈炘 邓存良
出处 《医学综述》 2008年第19期2897-2899,共3页 Medical Recapitulate
关键词 TOLL样受体4 乙型肝炎病毒 乙醇性肝病 肝纤维化 缺血/再灌注损伤 Toll-like receptor 4 HBV Alcoholic liver disease Hepatic fibrosis Ischemia/ reperfusion injury
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