摘要
糖尿病的发病机制是胰岛素抵抗和胰岛β细胞功能障碍。与胰岛素抵抗有关的因素有脂肪代谢异常、PTEN、抵抗素、白细胞介素6、肿瘤坏死因子α、C反应蛋白、脂联素、过氧化物酶体增殖物激活受体γ和胰岛素受体底物。胰岛β细胞既是胰岛素分泌细胞也是胰岛素作用的靶细胞。
The pathogenesy of Diabetes mellitus involves insulin resistence and dysfunction of β-cell of islet. The factors related to insulin resistance are adipose metabolic disorder, PTEN, resistin, interleukin-6, tumor necrosis factor-alpha, Creactive protein, adiponectin, the peroxisome proliferators-activated receptorgamma （PPAR-γ） and insulin receptor substrate. The β cell of islet is not only the secretory cell but also targeted cell of insulin.
出处
《医学综述》
2008年第19期2911-2914,共4页
Medical Recapitulate
关键词
糖尿病
胰岛素抵抗
脂联素
过氧化物酶体增殖物激活受体
胰岛素受体底物
Diabetes mellitus
Insulin resistance
Adiponectin
Peroxisome proliferators-activated receptor-gamma
Insulin receptor substrate
