肝细胞再生抑制肝损伤大鼠模型的构建

Animal model of hepatocytes anti-regeneration and liver injury

目的构建肝损伤合并自身肝细胞再生抑制动物模型。方法用2-乙酰氨基芴(AAF)灌喂大鼠后行肝部分切除,分时段检测肝功及肝脏再生情况。结果本方法建立的动物模型肝再生抑制明显(P<0.01),肝功能恢复缓慢(P<0.05)。结论肝损伤大鼠的肝细胞再生抑制明显,是较好的肝损伤合并自身肝细胞再生抑制动物模型。

Objective To establish the animal model of hepatocytes anti-regeneration and liver injure. Methods Rats were done the partial hepatectomy after feeding by AAF. Rats were detected the hepatic function and regeneration of hepatocytes by schedule. Results After feeding by AAF,the regeneration of hepatocytes in the liver injury rats was obviously in hibited（P〈0.01）. The recovery of hepatic function was slow（P〈0.05）. Conclusion There is obvious inhibition of hepatocyte regeneration in the liver injure rats. It is a good animal model of hepatocytes anti-regeneration and liver injure.