糖化血红蛋白在糖尿病诊断中的价值

Glycosylated Hemoglobin in the Diagnosis of Diabetes Mellitus

作者测定了66名受试者的空腹血糖,餐后1、2、3小时血糖,糖化血红蛋白(GHb),其中糖尿病患者34例,排除糖尿病及糖耐量减退者的正常人32名。结果显示糖尿病病人空腹血糖及餐后1、2、3小时血糖、血糖面积、GHb均显著高于正常人。所有受试者的GHb与空腹血糖、餐后2小时血糖、血糖面积均呈显著正相关。本文说明GHb诊断糖尿病的相对敏感性为88％,相对特异性为93.75％。

Blood glucose at fasting and 1. 2. and 3hours after meals GHb (glycosylated he-moglobin) were determined in 66 subjects.Based on WHO criterion, 34 of them werediabetics, and 32 were nondiabetics, inwhom impairing of glucose tolerance (IGT)and diabetes were ruled out. The resultsshowed that the concentrations of bloodglucose, at fasting, and 1, 2, and 3 hours aftermeals, blood glucose area,and GHb in diabeticpatients were significantly higher thanthose in the controls. There was a signifi-cant positive correlation between GHb andblood glucose at fasting and 2 hours aftermeal,and between GHb and blood glucosearea in all subjects. Relative sensitivity ofGHb for detecting diabetes mellitus was88％,and relative specificity was 93.75％.