大剂量肌醇治疗糖尿病外周神经病变疗效初步观察

Preliminary Report of Efficacy of Diabetic Polyneuropathy Treated with Large Dose Inositol

用大剂量肌醇片(每日6g)治疗糖尿病伴外周神经病变者10例,结果发现神经病变的临床症状得以缓解,但神经传导速度未全部得以改善。结合文献,讨论了临床症状和神经传导速度改善程度不一致的机理,并提出肌醇片不失为一种治疗糖尿病外周神经病变的有效药物之一,但对疗效的评价有待寻求新的指标。

Ten diabetics with polyneuropathywere studied by taking 6g inositol tablets(each tablet contains 0.25g inositol) perday for three months.The results showedthat large dose inositol could reduce the se-verity of clinical symptoms,but there wasno improvement of the nerve conductionvelocity .The possible mechanism of thesechanges was discussed. According to theclinical observation of the therapeuticeffect in those 10 cases, the authors woulddeem tha large dose inositol is an effec-tive drug for diabetic polyneuropathy, andit is worthy of further clinical trial, but othersensitive indicators should be usedtoevaluate the efficacy of this drug.