缬沙坦对急性冠脉综合征患者介入术后C-反应蛋白的影响

Effect of valsartan on level of C-reactive protein in acute coronary syndrome patients after PCI

目的探讨缬沙坦对急性冠脉综合征患者介入术后C-反应蛋白(CRP)水平的影响。方法将78例急性冠脉综合征介入治疗成功后的患者随机分为常规治疗组(40例)和缬沙坦组(38例)。两组分别于术前、术后24h、1个月、3个月、6个月测定C-反应蛋白(CRP)水平。结果缬沙坦组术后6个月CRP水平与常规治疗组之间差异均有统计学意义(P<0.05)。结论缬沙坦对急性冠脉综合征患者介入术后CRP的产生有抑制作用,可抑制介入术后炎症反应预防支架再狭窄。

Objective To investigate the effect of valsartan on the levels of C-reactive protein（CRP） in acute coronary syndrome patients after pereutaneous coronary intervention（PCI）Methods 78 acute coronary syndrome patients received sucessful PCI were randomly divided into conventional therapy group （40） and vasarhan group （38）.Venous blood samples were taken before,at 24 hours,1 month,3 months and 6 months after PCI in both groups, and serum samples were analyzed for CRP.Results At 6 months after PCI, the levels of CRP had statistical significant difference between the two groups （P〈0.05）.Conclusion Vasarltan can decrease the levels of CRP and suppress inflammatory reaction to prevent restenosis in stents in acute coronary syndrome patients after PCI.