期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

缺氧诱导因子-1对缺氧缺血性脑损伤的保护作用 被引量：6

Protective Role of Hypoxia Inducible Factor-1 on Hypoxia-Ischemia Brain Damage
下载PDF
导出
摘要 缺氧诱导因子-1(HIF-1)是异二聚体核转录因子,在维持细胞、组织氧平衡中起重要调节作用。由HIF-1α和HIF-1β2个亚单位组成。其中,HIF-1α是其功能亚基,缺氧条件下,HIF-1α与HIF-1β形成有活性的HIF-1,诱导下游靶基因的表达,通过调节不同靶基因而表现出不同的生理功能,如血管新生、能量代谢、红细胞生成、细胞分化等。在HIBD中,HIF-1α通过调节靶基因表达以增加组织氧供应、改善能量代谢、刺激血管新生与重塑、促进神经再生及抗凋亡等,从而达到神经保护作用。现阐述HIF-1的结构、生理功能及其在HIBD中的保护作用及机制。
作者 李丽华 张莉 屈艺 母得志
机构地区 四川大学华西第二医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2008年第18期1458-1460,共3页 Journal of Applied Clinical Pediatrics
基金 国家自然科学基金项目资助(30570623)
关键词 缺氧诱导因子-1 缺氧缺血性脑损伤 保护作用
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献20

  • 1Ivan M,Kondo K,Yang H,et al. HIFalpha targeted for VHL - mediated destruction by proline hydroxylation : Implications for O2 sensing [ J ]. Science,2001,292(5516) : 464 -468.
  • 2Peyssonaux C, Johnson RS. An unexpected role for hypoxic response: Oxygenation and inflammation [ J ]. Cell Cycle,2004,3 ( 2 ) : 168 - 171.
  • 3Komatsu DE,Hadjiargyrou M. Activation of the transcription factor HIF- 1 and its target genes, VEGF, HO - 1, iNOS, during fracture repair [J]. Bone,2004,34 (4) :680 - 688.
  • 4Sarada SK,Himadri P,Ruma D,et al. Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulattion of Bcl -2 [ J]. Brain Res ,2008 ,1209 :29 - 39.
  • 5Cho YS, Bae JM, Chun YS, et al. HIF - 1alpha controls keratinocyte proliferation by up - regulating p21 ( WAF1/Cip1 ) [ J ]. Biochim Biophys Acta,2008,1783 (2) :323 - 333.
  • 6Xu B,Doughman Y,Turakhia M,et cd. Partial rescue of defects in Cited2 - deficient embryos by HIF - 1 α heterozygosity [ J ]. Dev Biol, 2007,301 (1) :130 - 140.
  • 7Baregamian N, Rychahou PG, Hawkins HK, et al. Phosphatidylinositol 3 -kinase pathway regulates hypoxia - inducible factor - 1 to protect from intestinal injury during necrotizing enterocolitis [ J ]. Surgery,2007, 142(2) :295 -302.
  • 8Mu D, Chang YS, Vexler ZS, et al. Hypoxia - inducible factor 1 alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke[J]. Exp Neural,2005,195(2) :407 -415.
  • 9Mu D, Jiamg X, Shedon RA ,et al. Regulation of hypoxia -inducible factor 1 alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model[ J ]. Neurobiol Dis ,2003,14( 3 ) :524 - 534.
  • 10Nag S, Davis J, James H. Differential expression of vascular endothelial growth factor - A ( VEGF - A) and VEGF - B after brain injury[J]. J Neuropathol Exp Neurol,2002,61 (9) :778 - 788.

二级参考文献20

  • 1Ferriero DM. Neonatal brain injury. N Engl J Med, 2004,351 (19) : 1985-1995.
  • 2Greijer AE,van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol, 2004, 57 (10) : 1009-1014.
  • 3Goda N, Ryan HE, Khadivi B, et al. Hypoxia-inducible factor lalpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol, 2003,23(1) :359-369.
  • 4Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol, 2000,88(4):1474- 1480.
  • 5Helton R, Cui J, Scheel JR, et al. Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxicischemic damage. J Neurosci, 2005,25(16) :4099-4107.
  • 6Mu D, Jiang X, Sheldon RA, et al. Regulation of hypoxia-inducible factor 1αand induction of vascular endothelial growth factor in a rat neonatal stroke model. Neurobiol Dis, 2003,14 (3): 524-534.
  • 7Mu D, Chang YS, Vexler ZS, et al. Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. Exp Neurol, 2005,195(2):407-415.
  • 8Marti HJ, Bernaudin M, Bellail A, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol,2000, 156(3) :965-976,
  • 9Yeh WL, Lu DY, Lin CJ, et al. Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1α accumulation and VEGF expression. Mol Pharmacol, 2007,72(2) :440-449.
  • 10Studer L, Csete M, Lee SH, et al. Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. J Neurosci, 2000,20(19) :7377-7383.

共引文献19

同被引文献73

引证文献6

二级引证文献13

实用儿科临床杂志
2008年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部