肺部真菌感染的病原学及危险因素分析

ETIOLOGY AND RISK FACTOR ANALYSIS OF PULMONARY FUNGAL INFECTION

[目的]探讨肺部真菌感染(PFI)的病原学及危险因素。[方法]对2006年2月～2007年12月ICU住院发生肺部真菌感染的患者和同期住院未发生肺部真菌感染的对照组进行回顾性分析,同时对收集的病原菌进行病原学分析。[结果]肺部真菌感染的病原菌以白色念珠菌为主,大部分真菌对氟康唑耐药,对两性霉素B均敏感。高龄、广谱抗生素、基础疾病、侵入性操作、肠外营养、机械通气、激素的应用、免疫功能低下是肺部真菌感染的高危因素。[结论]控制和避免高危因素是减少肺部真菌感染的关键。两性霉素B是肺部真菌感染治疗的金标准。

[Objective] To analyze the etiology and risk factors of pulmonary fungal infection （PFI）. [Methods] From Feb. 2006 to Nov. 2007, 48 patients with PFI and 48 patients without PFI were selected in the study. The clinical data of these patients were retrospectively analyzed and the collected pathogens were analyzed. [Results] The majority pathogen of PFI was candida albieans. Most fungals were resistant to Flueonazole, all sensitive to Amphoteriein B.Eldly, broad-spectnun antibiotics, Advanced age, basic diseases, invasive operations, TPN, mechanical ventilation, glucocortieoid, immunocompromiee were risk factors of PFI. [Conclusion] Controllong and avoiding risk factors are the keys of decreasing PFI. Amphotericin B is gold standard for treating PFI.