抗细菌毒力的药物治疗

Therapy of Anti-bacterial Virulence

因各种耐药细菌的出现和蔓延,亟需开辟新的抗感染途径。抗细菌毒力靶向药物治疗能选择性地遏制目标菌的不同毒力因子如黏附素、细菌毒素、Ⅲ型分泌系统、细菌生物膜、群体感应及双组分系统等,有效预防和治疗多种感染疾病。这类药物并不直接影响菌体的存亡,故能有效降低细菌耐药的流行,弥补了现行抗感染药物的不足。

The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics require the discovery of new therapeutic approaches. Targeting bacterial virulence is an alternative approach to antimicrobial therapy that offers promising opportunities to inhibit pathogenesis and its consequences without placing immediate life-or-death pressure on the target bacterium. Certain virulence factors have been shown to be potential targets for drug design and therapeutic intervention, whereas new insights are crucial for exploiting others. Targeting virulence represents a new paradigm for the clinicians to prevent and treat infectious diseases more effectively.