正清风痛宁联合甲氨喋呤治疗类风湿关节炎

Effects of sinomenine combined with methotrexate on rheumatoid arthritis

目的评价正清风痛宁缓释片联合甲氨喋呤(MTX)治疗类风湿关节炎(RA)的疗效。方法RA患者69例,随机分成2组,正清风痛宁缓释片联合MTX治疗组35例,采用正清风痛宁缓释片2粒,每日2次口服,同时服用MTX10mg,每周1次;对照组34例,MTX10mg口服,每周1次,于治疗8周后,观察两组疗效。结果正清风痛宁组35例,其中显效21例,占60%,有效14例,占40%,无效0例,总有效率为100%;对照组34例,其中显效7例,占20.6%,有效24例,占70.6%,无效3例,占8.8%,总有效率为91.2%。两组疗效相比,经秩和检验,有显著性差异(P<0.05)。治疗组和对照组关节疼痛、肿胀、压痛、晨僵、血沉、C-反应蛋白、类风湿因子治疗后均明显低于治疗前(P<0.01或P<0.05)。治疗后正清风痛宁组与对照组晨僵、关节疼痛、肿胀、压痛、握力、ESR、CRP、PLT相比有显著差异(P<0.05)。结论正清风痛宁口服联合MTX治疗类风湿关节炎的疗效优于单用MTX组。

Objective To assess the effects of sinomenine combined with methotrexate on rheumatoid arthritis. Methods 69 patients of rheumatoid arthritis were randomly assigned to MTX ＋ SINOMENINE group （ n = 35） （MTX 10 mg, po, once a week, sinomenine 60 mg, po, twice a day） and MTX group （ n = 34） （ MTX 10 mg, po, once a week only）. All patients were followed-up fortnightly for 8 weeks. The disease activity was assessed with the help of 5 clinical and 3 laboratory indices. Results Patients in both groups showed significant decline in all indices. Marked, minor and no improvement were 21（60 % ）, 14 （40 % ） and 0 in the MTX ＋ SINOMENINE group arid 7 （20.6 % ）, 24 （70.6 % ） and 3 （8.8 % ） in MTX group respectively. Conclusion There are obvious effects of sinomenine combined with methotrexate on rheumatoid arthritis.