盐酸洛美沙星与甲硝唑氯化钠注射液配伍稳定性考察

Compatible stability of lomefloxacin hydrochloride with metronidazole and sodium chloride injection

目的探讨盐酸洛美沙星与甲硝唑氯化钠注射液的配伍稳定性。方法在室温、37℃恒温水浴条件下,应用双波长紫外分光光度法考察洛美沙星与甲硝唑氯化钠注射液配伍后6h内的含量变化,并观察配伍液外观及pH值变化。结果洛美沙星与甲硝唑氯化钠注射液配伍后外观、pH值及含量均无明显变化。结论注射用盐酸洛美沙星与甲硝唑氯化钠注射液在6h内可以配伍使用。

Objective To study the compatible stability of lomefloxaein hydrochloride with metronidazole and sodium chloride injection. Methods Changes in content were determined by dual-wavelength UV spectrophotometry within 6 h after the compatibility of lomefloxacin hydrochloride and metronidazole and sodium chloride injection at room temperature. The changes in appearance, pH of the compatible solution were observed by eye and acidimeter separately. Results The appearance, pH value and the content of lomefloxacin and metronidazole had no change within 6 h after the compatibility. Conclusion The lomefloxacin hydrochloride for injection and metronidazole and sodium chloride injection can be compatibly used, and they were stable within 6 h.