非何杰金淋巴瘤细胞白血病23例临床分析

Non-Hodgkin's Lymphoma Celi Leukemia (Clinical Analysis of 23 Cases)

143例非何杰金淋巴瘤病人中,23例发生了非何杰金淋巴瘤细胞白血病,发生率为16.8％。其中男性17例,女性6例,以30岁以下病人居多。从确诊非何杰金淋巴瘤到出现非何杰金淋巴瘤细胞白血病的时间为10天～11月。主要临床表现是淋巴结长大。病人接受COP或COPP方案治疗,疗效不理想。

In a group of 143 patients with non-hodgkin＇s Iymphoma(NHL), 23 patients(16.8%), of whom 17 cases were male and 6 female, mostly aged less than 30 years, were iden-tified to have NHL cell leukemia(NHLCL). The interval between the confirmations of NHL and NHLCL varied from 10 days to 11 months. The major presenting manifestation was lymphoadenopathy. Hb, WBC and Plt values were normal in most cases, but the tumor cells were present in every case, ranged from 1% to 90%. The bone marrow was cellular, with normal maturation of all hematopoietic elements. The remarkable finding was the presence of tumor cells, which occupied 6% to 90% of all nucleated cells. The infiltrating tumor cells were morphologically hetereogenous and might appear small, lar-ge or both in a patient. Most patients were treated with Copp regimen, but the over all results were unsatisfactory.