非编码核糖核酸与头颈部恶性肿瘤

Non-coding ribonucleic acid and head and neck cancer

非编码核糖核酸是一类具有重要生物学功能的核酸分子。目前,学术界仅对少数非编码核糖核酸的特性及其在细胞内的调控作用等有一定的认识,而对其他更多种类的非编码核糖核酸及其具体的生物学作用依然不甚明了。下面就非编码核糖核酸的主要分类、生物学意义和功能,以及非编码核糖核酸参与头颈部恶性肿瘤的发生及其在头颈部恶性肿瘤诊断、治疗中的应用作一简要综述。

Non-coding ribonucleic acid （ncRNA） is a kind of important functional biological molecule. Now, the property and role of regulation of few kind of ncRNA has been known in academic circles, but not more other kinds. This article briefly introduces the classification, biological significance and functions of ncRNA, and reviews the role of ncRNA in tumorigenesis, diagnosis and therapy of head and neck cancers.