单相抑郁与双相情感障碍遗传效应及方式的对照研究

A comparative study of genetic effect and model in unipolar and bipolar affective disorders

为寻找情感性障碍可能是一组异源性疾病的根据，调查了１７例单相抑郁和９６例双相情感障碍患者一、二级亲属中的情感性障碍患病率，并对二组亚型的遗传效应及方式作了对照分析。结果显示，单相抑郁的家族聚集性明显高于双相情感障碍。单相抑郁和双相情感障碍的加权平均遗传率分别为１３１．２％和８８．９％。单相抑郁和双相情感障碍都符合多基因遗传，但单相抑郁的遗传率明显高于双相情感障碍，且单相抑郁的二级亲属同病者均集中在母系。提示两者可能属异源性疾病。

In order to explore the hereditary feature in subtypes of affective disorders, a comparative study of genetic effects and models was carried out in 17 patients with unipolar depression and 96 patients with bipolar affective disorder. 2 268 first and second degree of relatives of probands had been interviewed. The results showed that the family cluster was significantly higher in unipolar than in bipolar patients (P<0.01). The weighed mean heritability was 131.2% in unipolar patients, and 88.9% in bipolar patients. The genetic model of two subtypes expressed as a polygenic heredity, but the heritability was higher in unipolar than in bipolar depression (P<0.05).