精神分裂症发病期及治疗缓解后诱发电位的变化

A study of variations of evoked potentials in episodical and remitted schizophrenics

为了解精神分裂症听觉（ＡＥＰ）、视觉（ＶＥＰ）、体感诱发电位（ＳＥＰ）特点以及治疗缓解后诱发电位（ＥＰ）变化，应用美国ＣＡ－１０００型电生理仪以及声、光、触三种刺激方法，对３１例精神分裂症患者作了ＥＰ检测，并对其中２５例作了ＥＰ随访。试验结果显示，在潜伏期上发现，患者组ＡＥＰ／Ｐ２、ＶＥＰ／Ｐ２、ＳＥＰ／Ｐ２前移（Ｐ＜０．０５），ＡＥＰ／Ｐ１、ＶＥＰ／Ｎ２和ＳＥＰ／Ｎ１也提前（Ｐ＜０．０５），但ＡＥＰ／Ｐ３延迟（Ｐ＜０．０５）。波幅表明，患者组ＡＥＰ／Ｎ１－Ｐ２、ＶＥＰ／Ｎ１－Ｐ２、ＶＥＰ／Ｐ２以及ＳＥＰ／Ｐ２－Ｎ２降低（Ｐ＜０．０５）。随访提示，患者组康复时波形稳定，ＶＥＰ／Ｎ１－Ｐ２和ＳＥＰ／Ｐ２－Ｎ２波幅增高，ＡＥＰ／Ｐ２、ＶＥＰ／Ｐ２以及ＡＥＰ／Ｐ１数值恢复至正常对照内（Ｐ＜０．０５）。初步认为，三种成熟的感觉性ＥＰ作为本病状态标记的价值，值得进一步探讨。

In order to investigate the feature of brain evoked potential (BEPs) in schizophrenics and the change of BEPs between duration of episode and remission, BEPs were measured using a CA1000 Model BEP Instrument (made in USA) with stimuli of auditory, visual, and somatosensory modalities in 25 schizophrenic patients in a clinical followup study. The main variations of BEPs in schizophrenic group were as following. Shorter latency was found to be associated with P2 of auditory evoked potential (AEP), visual evoked potential (VEP) and somatosensory evoked potential (SEP) (P<0.05), P1 of AEP, N2 of VEP, and N1 of SEP (P<0.05); Longer latency was found to be associated with P3 of AEP (P<0.05); Diminished amplitude was found to be associated with N1P2 of AEP and N1P2 of VEP, P2 of VEP, and P2N2 of SEP (P<0.05). The followup study revealed that, when the psychiatric symptoms remitted, the waveform of their BEPs became more steady, amplitude N1P2 of VEP and P2N2 of SEP was increased (P<0.05); The amplitude P2 of AEP and VEP, and P1 of AEP, was increased into the normal range. The results suggest that AEP, VEP, and SEP may have a referential value in diagnosing of schizophrenia and scanning for the predisposed sample. This study supports that the variations of BEPs may be the state markers of schizophrenia