急性脑梗死患者血浆单核细胞趋化蛋白-1和组织因子水平的变化

Change of Plasma Monocyte Chemotactic Protein 1 and Tissue Factor of Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死患者血浆单核细胞趋化蛋白-1和组织因子的变化及临床意义。方法:对56例急性脑梗死患者脑梗死组和30例健康者对照组应用酶联免疫吸附双抗体夹心法(EL ISA法)定量测定血浆单核细胞趋化蛋白-1和组织因子的水平。结果:与正常对照组相比,脑梗死组血浆单核细胞趋化蛋白-1含量(128.49±76.97)ng/L和组织因子含量(424.23±189.87)ng/L明显高于对照组的单核细胞趋化蛋白-1含量(49.21±29.36)ng/L和组织因子含量(109.25±42.98)ng/L,差异具有显著性(P<0.01)。随急性脑梗死患者病情严重程度的加重,血浆单核细胞趋化蛋白-1的含量增高越明显。结论:急性脑梗死患者血浆单核细胞趋化蛋白-1和组织因子的水平明显升高,并且与急性脑梗死患者的病情密切相关。

Objective：To investigate the changes of plasma monocyte chemotactic protein 1 （MCP-1）and tissue factor （TF） of patients with acute cerebral infarction and it＇s clinical significance. Methods ：The plasma level of MCP-1 and TF were measured by sandwich ELISA in 56 patients with cerebral infarction and 30 normal healthy subjects. Resuits ：Compared with MCP-1 （49.21 ± 29. 36 ng/L） and TF （109. 25 ± 42. 98 ng/L） in healthy control group, patients with cerebral infarction had higher levels of MCP-1 （128.49 ± 76.97 ng/L） and TF （424.23 ± 189.87 ng/L）, and there were distinctly difference （P〈0.01）. The severer the patient＇s degrees was,the MCP-1 and TF higher were. Conclusions ：Plasma MCP-1 and TF level are increased at early stage in patients with cerebral infarction. The MCP-1 and TF level is helpful to evaluate the severity of the patients with cerebral infarction.