摘要
Adenine is an important chemical material widely used in the fields of medicine,organic synthesis and so on.Presently,adenine is produced from the condensation of diethyl malonate with formamide,which has serious pollution problems.To achieve the green production of adenine,non-catalyzed hydrolysis of adenosine in high temperature liquid water was carried out.The effects of initial concentration,agitating speed and temperature on adenosine hydrolysis were studied and the kinetics of adenosine hydrolysis was investigated at temperatures from 150℃ to 190℃.Rate constants were evaluated with the zeroth-order reaction assumption and the activation energy was 134.1 kJ·mol-1.The experimental results demonstrated that high selective preparation of adenine by non-catalyzed hydrolysis of adenosine in high temperature liquid water was possible.
Adenine is an important chemical material widely used in the fields of medicine, organic synthesis and so on. Presently, adenine is produced from the condensation of diethyl malonate with formamide, which has serious pollution problems. To achieve the green production of adenine, non-catalyzed hydrolysis of adenosine in high temperature liquid water was carried out. The effects of initial concentration, agitating speed and temperature on adenosine hydrolysis were studied and the kinetics of adenosine hydrolysis was investigated at temperatures from 150℃ to 190℃. Rate constants were evaluated with the zeroth order reaction assumption and the activation energy was 134. 1 kJ·mol^-1 .The experimental results demonstrated that high selective preparation of adenine by non-catalyzed hydrolysis of adenosine in high temperature liquid water was possible.
出处
《化工学报》
EI
CAS
CSCD
北大核心
2008年第10期2531-2535,共5页
CIESC Journal
基金
国家自然科学基金项目(20674068)
高等学校博士学科点专项科研基金(20050335099)~~
关键词
腺苷
无催化水解
腺嘌呤
高温液态水
adenosine
non-catalyzed hydrolysis
adenine
high temperature liquid water
