摘要
Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mito- chondrial disease study.
Mitochondrial disease currently received an increasing concern. However, the case-control design commonly adopted in this field is vulnerable to genetic background, population stratification and poor data quality. Although the phylogenetic analysis could help solve part of these problems, it has not received adequate attention. This paper is a review of this method as well as its application in mitochondrial disease study.
作者
WANG ChengYe1,2,3, KONG QingPeng1,2 & ZHANG YaPing1,2? 1 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
2 Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, China
3 Graduate University of Chinese Academy of Sciences, Beijing 100049, China
基金
the National Natural Science Foundation of China (Grant No. 30621092)
Science and Technology Committee of Yunnan Province (Grant No. 312007C103M01)
关键词
线粒体
疾病分析
单元型
种群分布
mitochondrial disease, phylogenetic analysis, haplotype, data quality, population stratification
