线粒体融合蛋白2、PCNA在非小细胞肺癌组织中的表达及意义

Expression and Significance of Mitofusin 2 and Proliferating Cell Nuclear Antigen in Non-small Cell Lung Cancer

目的:探讨非小细胞肺癌(NSCLC)中线粒体融合蛋白2(Mfn2)、增殖细胞核抗原(PCNA)的表达与临床病理特征之间的关系及二者的相关性。方法:采用免疫组化SP法检测92例非小细胞肺癌组织中Mfn2、PCNA的表达。结果:肺鳞癌组织中Mfn2的表达(IOD值)高于腺癌(P<0.01),高分化、中分化的肺癌组织中Mfn2的表达高于低分化的肺癌组织(P<0.01);PCNA在肺癌组织中的表达(IOD值)随分化程度的降低而升高,高、中分化与低分化组相比较,差异均有统计学意义(P<0.05或P<0.01);有淋巴结转移组PCNA的表达高于无淋巴结转移组(P<0.01)。结论:Mfn2在非小细胞肺癌中的表达与组织学分型、分化程度有关;PCNA在非小细胞肺癌组织中的表达与分化程度、淋巴结转移有关,且二者的表达呈负相关。

Objective： To investigate the relationship between the expressions of mitofusin 2 （Mfn2） and proliferating cell nuclear antigen（PCNA）and clinical pathological feature of non-small cell lung cancer （NSCLC）. Methods： The expres-sions of Mfn2 and PCNA were detected in 92 samples of NSCLC by immunohistochemistry. Results： The integral optical density （IOD） value of Mfn2 expression was significantly higher in squamous cell carcinoma than that in adenocarcinoma （P 〈 0.01）. The value of IOD was much higher in ranking high-middle differentiation group than that in low differentiation group（P 〈 0.01）. The IOD value of the expression of PCNA was increased with the decrease of differentiation degree,which showed statistical significance between high-middle and low differentiation group（P 〈 0.01 or P 〈 0.05）. The expression of PCNA was obviously higher in lung cancer with lymph node metastasis than that in lung cancer without lymph node metasta-sis. Conclusion： The IOD value of the expression of Mfn2 in NSCLC was associated with histological type and tumor differ-entiation. The IOD value of the expression of PCNA was closely associated with tumor differentiation and lymph node metas-tasis. There was a negative correlation between expressions of Mfn2 and PCNA in NSCLC.