中药治疗肝癌在实验研究领域的发展现状及趋势

Current situation and prospects of experimental researches on treatment of hepatoma using traditional Chinese herbs

中医药在肝癌的治疗中发挥着不可替代的作用,中西医结合治疗已成为肝癌治疗的一种重要手段.通过综述近些年中药治疗肝癌的相关实验研究文献,研究者认为中药主要通过诱导癌细胞凋亡、抑制癌细胞增殖及直接杀伤癌细胞、诱导癌细胞分化、抑制端粒酶活性、调节细胞信号转导、调节机体免疫功能、抑制肿瘤血管生成、逆转肿瘤多药耐药性等作用环节,从而达到治疗肝癌的目的.以研究中药有效部位群的作用靶点为突破口,开发新型抗癌药物,将成为癌症药物治疗领域的研究热点.

Traditional Chinese herbs play an important and irreplaceable role in the treatment of hepatocellular carcinoma nowadays.Through reviewing the recent experimental researches,we consider that traditional Chinese herbs produce the anticancer effect by inducing hepatoma cell apoptosis,altering the cell cycle,restraining the expression of carcinoma-related genes,decreas- ing the telomerase’s activity,regulating the cell signaling pathway,inhibiting the angiogenesis of tumors,improving the host immune function and reversing the multidrug resistance of cancer cells.It is becoming a hotspot to study the effective parts and components of traditional Chinese herbs for developing new effective antitumor drugs.