期刊文献+

基于微丝的PDMS微流动通道制作技术 被引量:4

原文传递
导出
摘要 微流动通道是微流控芯片的重要组成部分,其加工技术的每一步进化或简化一直为国际学术界与工业界所重视.提出了一种基于微丝的PDMS微流动通道制作技术.该技术利用一些简单的模具辅助固定和布置微丝,然后将PDMS预聚物浇注于模具中浸没微丝并固化,固化后抽出微丝形成PDMS微通道或通道阵列,在与通道垂直的方向上打孔并封装,形成与通道外部物质交换的接口.实际制作通道时可采用商用化的金属微丝(如不锈钢微丝),直径从100~20μm不等.较为详细地介绍了利用这种技术来构建多种拓扑结构的二维或三维通道或通道阵列,例如直通道、交叉通道、弯曲通道等的能力.进一步,基于金属微丝的电磁特性,这样的微通道制作工艺还被应用来构建出适于电磁控制和温度控制的微流动通道装置.最后,通过圆截面微通道的光路分析、微通道内粒子流动的图像测速(Micro-PIV)与微液滴形成实验及分析进一步印证了这种微流动通道制作技术的可行性和适用性。
出处 《科学通报》 EI CAS CSCD 北大核心 2008年第17期2116-2124,共9页 Chinese Science Bulletin
基金 科技部国际科技合作重点项目(编号:2005DFA00190) 国家"111计划"(编号:B06023) 重庆大学研究生科技创新基金(编号:200707A1A0110248)资助
  • 相关文献

参考文献26

  • 1Whitesides G M. The origins and the future of microfluidics. Nature, 2006, 442:368--373.
  • 2Chen C, Hirdes D, Folch A. Gray-scale photolithography using microfluidic photomasks. Proc Natl Acad Sci USA, 2003, 100: 1499-- 1504.
  • 3Ikuta K, Hirowatiri H, Ogata Y. Three dimensional micro integrated fluid systems (MIFS) fabricated by stereo lithography. Proceedings IEEE Micro Electro Mechanical Systems (MEMS'94), Oiso, Japan, 1994. 1--6.
  • 4Bloomstein T M, Ehrlich D J. Laser-chemical three-dimensional wridng for microelectromechanics and application to standard-cell microfluidics. J Vac Sci Technol B, 1992, 10:2671--2674.
  • 5Gonzalez C, Smith R L, Howitt D G, et al. Microjoinery: Concept, definition, and application to microsystem development. Sens Actu A, 1998, 66:315--332.
  • 6Jo B H, van Lerberghe L M, Motsegood K M, et al. Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer. J Micro Electro Mech Sys, 2000, 9:76--81.
  • 7Xia Y, Whitesides G M. Soft lithography. Angew Chem Int Ed, 1998, 37:550--575.
  • 8Kumar A, Whitesides G M. Formation of microstamped patterns on surfaces and derivative articles. U.S. Patent, 5512131, 1997.
  • 9Chert C S, Mrksich M, Huang S, et al. Geometric control of cell life and death. Science, 1997, 276:1425--1428.
  • 10Bernard A, Delamarehe E, Schmid H, et al. Printing patterns of proteins. Langmuir, 1998, 14:2225--2229.

二级参考文献3

共引文献16

同被引文献56

  • 1陈慧清,朱庆欢,许海娟.微流控芯片荧光检测的研究[J].实验室研究与探索,2007,26(6):23-25. 被引量:5
  • 2Abhyankar V V, Toepke M W, Cortesio C L, et al. A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab Chip, 2008, 8:1507-1515.
  • 3Keenan T M, Folch A. Biomolecular gradients in cell culture systems. Lab Chip, 2008, 8:34-57.
  • 4Boyden S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med, 1962, 115:453-466.
  • 5Bourguignon L Y, Zhu H, Shao L, et al. CD44 interaction with tiaml promotes Racl signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem, 2000, 275:1829-1838.
  • 6Saadi W, Rhee S W, Lin F, et al. Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber. Biomed Microdevices, 2007, 9:627-635.
  • 7Chen C, Hirdes D, Folch A. Gray-scale photolithography using microfluidic photomasks. Proc Natl Acad Sci USA, 2003, 100:1499-1504.
  • 8Kumar A, Whitesides G M. Formation of microstamped patterns on surfaces and derivative articles. U.S. Patent, 5512131, 1997.
  • 9Verma M K S, Majumder A, Ghatak A. Embedded template-assisted fabrication of complex microchannels in PDMS and design of a microfluidic adhesive. Langmuir, 2006, 22:10291-10295.
  • 10Song S H, Lee C K, Kim T J, et al. A rapid and simple fabrication method for 3-dimensional circular microfluidic channel using metal wire removal process. Microfluid Nanofluid, 2010, 9:533-540.

引证文献4

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部