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乳腺癌的分子分型 被引量：12

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摘要 乳腺癌是多基因参与、多步骤发生的恶性肿瘤，基因表达谱的不同使得乳腺癌具有不同的生物学特征，而乳腺癌的异质性导致了病理分期相同的患者对临床治疗的反应及预后会有很大差别。确定一种能够准确反映乳腺癌治疗疗效及预后的分型，对于进行个体化治疗和改善乳腺癌患者的预后具有重要意义。基因芯片技术的开发利用，
作者 陈小松 陈舒婕 沈坤炜
机构地区 复旦大学上海医学院肿瘤学系复旦大学附属肿瘤医院乳腺外科
出处 《中华肿瘤杂志》 CAS CSCD 北大核心 2008年第9期641-643,共3页 Chinese Journal of Oncology
关键词 乳腺肿瘤 分子分型 基因表达图谱 Breast neoplasms Molecular classification Gene expression profiles
分类号 R686 [医药卫生—骨科学]
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参考文献24

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同被引文献141

  • 1王之敏,陶承.恶性脑胶质瘤分子靶向治疗研究进展[J].中国肿瘤,2006,15(3):158-162. 被引量：3
  • 2方家椿.分子靶点和分子靶向抗肿瘤药研究进展[J].北京大学学报（医学版）,2006,38(6):575-578. 被引量：12
  • 3DietelM,Sers C.Personalized medicine and development of targeted therapies:the upcoming challenge for diagnostic molecular pathology A review.Virchows Arch,2006,448(6):744-755
  • 4Iorio MV,ferracin M,Liu GG et al,microRNA gene expression deregulation in human breast cancer.Cancer Res,2005,65(16):7065-7070
  • 5Regnolds MA,Kasturg K,Groskopf J,et al.molecular makers for prostate cancer.Cancer Lett,2007,249(1):5-13
  • 6Jass JR.Toward a molecular classification of colorectal cancer[J].Int J Colorectal Dis,1999,14(4-5):194-200
  • 7Giordano TJ,Shedden KA,Schwartz DR,et al.Organ-specific molecular classification of primary lung,colon,and ovarian adenocarinomas using gene expression profiles.Am J Pathol,2001,159(4):1231-1238
  • 8Van′t Veer LJ,Dai H,van de Vijver MJ,et al.Expression profiling predicts outcome in breast cancer.Breast Cancer Res,2003,5(1):57-58
  • 9Perez-Enciso M,TenenhausM.Predition of clinical outcome with microarray data:a partial least squares discriminant analysis(PLS-DA)approach.Hum Genet,2003,112(5-6):581-592
  • 10Kallioniem AK,Kallioniemi OP,Sudar D.Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors.Science,1992,258(5083):818-821

引证文献12

二级引证文献31

中华肿瘤杂志
2008年 第9期

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