茶多酚对染铅小鼠NO、NOS、MDA、SOD的影响

Effects of tea polyphenol on NOS,NO,SOD and MDA in rats of lead exposure

目的:探讨茶多酚对染铅小鼠血清的一氧化氮(NO)含量与一氧化氮合酶(NOS)的活力、脑与肝的丙二醛(MDA)含量和SOD活力的影响。方法:小鼠经饮水(加0,0.1,0.1g·L-1铅离子),分别供空白组、模型组、治疗组自由饮用染毒,测定各组织或器官的NO和MDA含量以及SOD与NOS的活力。结果:茶多酚一定程度上能升高NO的含量,降低脑及肝内MDA的水平,同时亦能复活NOS及SOD的活力。结论:茶多酚对染铅动物的各项治疗均有一定程度的效果,但治疗及各项生化指标的恢复均有限。

OBJECTIVE To study effects of the tea polyphenol to rats exposed to the lead on activity of nitrico xide synthase （NOS） in blood and superoxide dismutase（SOD） in brain and liver, as well as concentration level of nitricoxide（NO） in blood and malondialdehyde（MDA） in brain and liver. METHODS Rats were exposed to lead by drinking （0, 0. 1, and 0. 1 g.L Pb-2＋ ）lead acetate solution as the control group,model group and therapeutic group. Respectively. Activities of NOS and SOD, and concentration levels of NO and MDA were measured. RESULTS The tea polyphenol could increase the level of NO, decease brain and liver levels of MDA, restore the activity of NOS and SOD. CONCLUSION The tee polyphenols have certain effect of the treatment of lead exposured rats, but the recovery is not significant.