罗格列酮对2型糖尿病合并高血压患者血糖及血压的作用观察

Effect of rosiglitazone on blood glucose and blood pressure in type 2 diabetic patients combined with hypertension

目的:探讨罗格列酮对2型糖尿病合并高血压患者血压的影响。方法:90例2型糖尿病合并高血压并存在胰岛素抵抗患者,继续服用原降压药和控制饮食运动的基础上,给与罗格列酮剂量4～8mg·d-1,疗程12周。治疗前后测血糖、Ins和HbA1c以及血压的变化。结果:治疗12周后SBP、DBP明显下降(P<0.01)。治疗前后的FPG、PPG、FINS、PINS变化比较差异均有显著性(P<0.05),体质量水平治疗前后比较差异无显著性(P>0.05)。结论:罗格列酮在降低血糖,改善胰岛素抵抗的同时,具有一定程度降低血压的作用。

OBJECTIVE To explore the effect of rosiglitazone on type 2 diabetic patients combined with hypertension. METHODS The 90 type 2 diabetic patients combined with hypertension were treated with rosiglitazone （4 - 8 mg.d-1 ） for 12 weeks on the basis of former hypotensive drug administration, alimentary control and exercise. Blood pressure, Ins and HbAlc were measured before and after treatment with rosiglitazone. RESULTS After 12 weeks of treatment, SBP and DIBP were low- ered significantly （P〈0. 01 ）. The levels of FPG, PPG, FINS and PINS changed significantly compared with those before treat- ment（P〈0. 05）,there was no significant change in patients＇ weight（P〉0. 05）. CONCLUSION Rosiglitazone decreases blood glucose and improves insulin resistance, at the same time, it also lowers blood pressure in type 2 diabetes combined with hyper tension.