摘要
目的观察葛根素注射液对早期糖尿病肾病患者血液流变学和血清可溶性细胞粘附分子-1(sI-CAM-1)的影响。方法将76例早期糖尿病肾病患者随机分为治疗组(42例)和对照组(34例)。两组均采用饮食控制和糖尿病常规治疗,治疗组加用葛根素注射液治疗,疗程3周。结果治疗组血液流变学各项指标较治疗前显著下降(P<0.05);尿白蛋白排泄率、血可溶性粘附分子-1(sICAM-1)均明显下降(P<0.01),且明显优于对照组(P<0.05)。结论葛根素注射液能改善早期糖尿病肾病患者的血液流变性和微循环,减少尿白蛋白的排出,降低血清sICAM-1水平,减轻肾损害。
Objective To observe the influence of treatment with puerarin injection on changes of hemorrheology and serum soluble intercellular adhesion molecule - 1 （slCAM - 1 ） in patients with early diabetic nephropathy （EDN）. Methods Seventy - six patients with early diabetic nephropathy were randomly divided into two groups. The control group （n = 34） was treated with conventional therapy for diabetes and diet control method,while the treatment group （n = 42） was treated with puerarin injection additionally. The therapeutic course was 3 weeks. Results In the treatment group, the hemorrheological parameters were significantly decreased （ P 〈 0.05 ）, the levels of urinaryalbumin excretion rate （UAER） ,the levels of serum soluble intercellular adhesion molecule - 1 （ sICAM - 1 ） were also significantly decreased compared to those before therapy （ P 〈 0.01 ）. The changes in the treatment group were superior to those of the control group. Conclusions The treatment of puerarin injection for patiens with early DN can decrease the parameters of hemorrheology, improve microcirculation, decrease UAER and the levels of serum soluble intercellular adhesion molecule - 1 （ sICAM - 1 ） , ameliorate renal injury.
出处
《医学信息（手术学分册）》
2008年第7期612-614,共3页
Medical Information Operations Sciences Fascicule
