国产头孢克肟颗粒的溶出度比较

Comparison of Dissolution for Domestic Manufacturers Cefixime Particles

目的比较国内3个不同厂家生产的头孢克肟颗粒的溶出性能。方法分别采用水、0.1mol/L盐酸溶液、pH7.0磷酸盐缓冲液3种溶出介质,搅拌浆法,转速为50r/min对各头孢克肟颗粒进行溶出度测定。结果3个厂家的头孢克肟颗粒在不同溶出介质中溶出均较好,其中在pH7.0磷酸盐缓冲液介质中溶出效果最佳,在45min时累积溶出量分别为50.03mg、49.74mg、49.79mg。结论国内部分厂家生产的头孢克肟颗粒内在质量均较好,相互间无明显差异。

Objective Comparing three different domestic manufacturers cefixime dissolution of the particles. Methods By using water, 0. 1mol/L hydrochloric acid, pHT. 0 PBS three kinds of dissolution media, Stir paste, Speed for 50r/min, Cefixime on the dissolution of particles. Results Three manufacturers of cefixime particles in different dissolution medium dissolution are better, In the pHT. 0 PBS medium stripping the best results in 45 min, the cumulative volume for the dissolution are 50.03 mg, 49.74mg, 49.79mg. Conclusion Some domestic manufacturers cefixime particles are better internal quality, No significant differences between each other.