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尼莫地平、MK-801对海马迟发性神经元坏死治疗作用的实验研究 被引量：2

The treatment role of nimodipine and MK801 in hippocampal delayed neuron death
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摘要 采用大鼠全脑缺血模型、观察脑缺血再灌流过程中海马神经元的病理变化，并用尼莫地平（钙拮抗剂）及ＭＫ－８０１（ＮＭＤＡ受体拮抗剂）治疗，观察其对迟发性神经元坏死的疗效，旨在探讨钙及兴奋性氨基酸在海马神经元缺血损害中的作用，为缺血性脑损伤的治疗探索新的途径。 Hippocampal pathologic changes were observed during ischemia and postischemic reperfusion in fourvessels occlusion in ischemic rats. The effects of MK801 and nimodipine were also examined. Our results suggested nimodipine and MK801 can ptotect hippocampus from delayed neuron death.
作者 黎红华 郑彩梅
机构地区 广州军区武汉总医院普内科 重庆第三军医大学西南医院神经内科
出处 《卒中与神经疾病》 1997年第4期203-205,共3页 Stroke and Nervous Diseases
关键词 脑缺血 海马 MK-801 尼莫地平 Rat Hippocampus Cerebral ischemia MK801 Nimodipine
分类号 R743.310.5 [医药卫生—神经病学与精神病学] R972 [医药卫生—药品]
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  • 1DeGraba TJ, Pettigrew LC. Why do neuroprotective drugs working animals but not humans [J] ? Neurol Clin, 2000,18(2):475-493
  • 2Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke, 1989,20(1) :84-91
  • 3Lenden PD, Jackson-Friedman C, Shin C, et al. Synergistic combinatorial stroke therapy: Aquantabioassay of a GABA agonist and a glutamate anta-gonist[J]. Exp Neurol, 2000 , 163(2):477-489
  • 4Hick CA, Ward MA, Swettenham JB, et al. Synergistic neuroprotective effects by combining a NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischemia[J].Eur J Pharmacol,1999,381(2-3) :113-119
  • 5Dezsi L,Greenberg JH,Hamar J,et al.Acute improvement in histological outcome by MK-801 following focal cerebral ischemia and reperfusion in the cat independent of blood flow changes.J Cereb Blood Flow Metab,1992,12:390 -399.
  • 6Liniger R,Popovic R,Sullivan B,et al.Effects of neuroprotective cocktails on hippocampal neuron death in an in vitro model of cerebral ischemia.J Neurosurg Anesthesiol,2001,13:19-25.
  • 7Farias LA,Smith EE,Markov AK.Prevention of ischemic-hypoxic brain injury and death in rabbits with fructose-1,6-diphosphate.Stroke,1990,21:606-613.
  • 8Gregory GA,Welsh FA,Yu AC,et al.Fructose-l,6-bisphosphate reduces ATP loss from hypoxic astrocytes.Brain Res,1990,516:310 -312.
  • 9Durmaz R,Inal M,Angin K,et al.The effects of MK-801 and U83836E on post-ischemic reperfusion injury in rat brain.Acta Neurobiol Exp (Wars),1999,59:99-104.
  • 10Cuzzocrea S,Mazzon E,Costantino G,et al.Beneficial effects of nacetylcysteine on ischaemic brain injury.Br J Pharmacol,2000,130:1219-1226.

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卒中与神经疾病
1997年 第4期

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