摘要
采用大鼠全脑缺血模型、观察脑缺血再灌流过程中海马神经元的病理变化,并用尼莫地平(钙拮抗剂)及MK-801(NMDA受体拮抗剂)治疗,观察其对迟发性神经元坏死的疗效,旨在探讨钙及兴奋性氨基酸在海马神经元缺血损害中的作用,为缺血性脑损伤的治疗探索新的途径。
Hippocampal pathologic changes were observed during ischemia and postischemic reperfusion in fourvessels occlusion in ischemic rats. The effects of MK801 and nimodipine were also examined. Our results suggested nimodipine and MK801 can ptotect hippocampus from delayed neuron death.
出处
《卒中与神经疾病》
1997年第4期203-205,共3页
Stroke and Nervous Diseases