添加拉莫三嗪治疗难治性癫痫

Lamotrigine as Add-on Drug in the Management of Intractable Epilepsy

采用保持原用抗病药物及剂量不变，添加拉莫三嗪（LTG）治疗161例难治性痛痛患者。以治疗前3个月的发作次数为基础，与治疗期间3个月内发作次数比较，结果显示：添加LTG后癫痫发作完全控制者12例，占7．45％；明显好转者69例，占42．8％。其中全身强直-阵挛发作者疗效最佳，其明显好转者为48．52％，部分性发作者中明显好转者为44％。Lennox－Gastaut综合征8例，明显好转者50％。该药副作用小，减量或停药后症状消失。

Objective To evaluate efficiency and safety of lamotrigine (LTG) in patients with refractory epilepsy. Methods 161 patients with refractory epilepsy were treated by LTG as add-on therapy to the original antiepileptic drugs with dosages unchanged. Seizure counts in 3 months before and during LTG treatment were compared. Results 12 patients (7. 45% ) became seizure-free, significant decrease of seizure was obtained in patients with generalized tonicoclonic seizure(48. 52 % of which was significantly efficient). Significant efficiency was obtained in 44% of patients with partial seizures. 4 cases of Lennox-Gastaut syndrome were significant efficiency in total & cases. The adverse events of LTG were generally mild and would disappeared when the dose was decreased or the medication was discontinued.Conclusion Our findings showed LTG was effective, safe and well tolerated as add-on therapy for refractory epileptic seizures.