摘要
神经肽Y（NPY）是广泛分布于中枢神经系统和外周神经各部位的神经肽类物质。本实验观察NPY在体外对几种免疫细胞活性的直接作用。结果表明，NPY对小鼠T淋巴细胞丝裂原反应性和NK细胞的杀伤活性均无明显影响（P＞0．05），对巨噬细胞分泌溶菌酶有明显抑制作用（P＜0．05）；而对B淋巴细胞丝裂原反应性则有明显的促进作用（P＜0．05）。上述结果提示，NPY对部分免疫细胞功能的影响因细胞种类而异。
Objective The vitro effects of neuropeptide Y(NPY) on several kinds of immunocytes in mice were observed in this study. Methods By means of cell culture, the effects of NPY on the mitogenesis of T and B lymphocytes, the cytotoxic activities of NK cells and the lysozyme secretion from macrophages were investigated in vitro. Results The results indicated that NPY had no effect on the mitogenesis of T lymphocytes and the cytotoxic activites of NK cells (P＞0. 05), in contrast, significantly enhanced the mitogenesis of B lymphocytes(P＜0. 05) and inhibited the lysozyme secretion from macrophages (P＜0. 05). Conclusion These findings suggest that NPY has different effects on the functions of different kinds ofimmunocytes.
出处
《中国神经免疫学和神经病学杂志》
CAS
1997年第4期244-247,共4页
Chinese Journal of Neuroimmunology and Neurology
