甲状旁腺素、血小板胞浆游离钙在尿毒症患者血压调节中的作用

Role of parathyroid hormone and platelet cytosolic free calcium in regulation of blood pressure in uremic patients

目的 了解血透患者甲状旁腺素[PTH(1～84)]和血小板胞内游离钙浓度{pt[Ca^(2+)]i}在血压调节中的作用。方法 用Fura-2荧光测定法和免疫放射法对24例血透患者测定上述两项内容。结果 HD患者的静息pt[Ca^(2+)]i和PTH(1～84)是升高的,高血压者升高更为明显。静息pt[Ca^(2+)]i与PTH(1～84)相关。多因素逐步回归显示PTH(1～84)、pt[Ca^(2+)]i为影响HD患者平均动脉压的主要因素。结论 PTH(1～84)、pt[Ca^(2+)]i可能是主要影响尿毒症患者血压的因素。

To observe the role of parathyroid hormone PTH( 1 - 84) and platelet cytosolic free calcium I pt[ Ca2 + ] i in regulation of blood pressure on hemodialysis (HD) patients. Methods Fura-2 fluorometry and immunoradioassy werw used to detect PTH(1 - 84) and pttCa2+ ]i in 24 HD patients. Results The resting pt[Ca?+ ]i and PTH(1 - 84) increased in HD cases, and they were significantly higher in uremic patients with hypertension than ones without hypertension. The resting pt[Ca2+ ]i was correlated to PTH( 1 - 84) in HD cases. The multivariate stepwise regression analysis showed the PTH( 1 - 84) and pt[Ca2 + ]i are probably mains factors to affect the blood pressure in HD cases. Conclusion PTH(l - 84) and pt[Ca2+ ji are main factors affecting the blood pressure in uremic patients.