激素移行减量法治疗儿童肾病综合征的疗效观察

Hormone treatment of children in transitional reduction of the effect of nephrotic syndrome

目的观察激素移行减量法治疗儿童原发性肾病综合征的疗效。方法激素选择强的松。将31例肾病综合征患儿随机分为A、B两组；A组巩固维持阶段采用移行减量方法，B组采用隔日顿服方法。观察两组患儿治疗前后尿蛋白、血清白蛋白、血尿素氮、血肌酐等，根据随访资料了解复发情况。结果A组15例，完全缓解8例，部分缓解5例，缓解时间86．5d，无效2例，复发3例；B组16例，完全缓解9例，部分缓解5例，缓解时间86．5d，无效2例，复发9例。结论A、B两组近期缓解率及达到缓解所需时间无差别，但A组复发率明显降低，肾功能改善更为显著。

Objective Observation of transitional reduction of hormone treatment of children with nephrotic syndrome effect. Methods The hormone chooses the strong pine. Divides into A, B stochastically 31 example nephrosis syndrome baby two groups; A group of consolidated maintenance stage uses divides and hyphenates a word at the end the decrement method, B group uses every other day the clothing method. Around observes two group of babies to treat the urine protein, the serum albumin, the blood urea nitrogen, the blood myo- bitter wine and so on, according to revisit material understanding recrudescence situation. Results A group of 15 cases, complete remission eight cases, five cases of partial response, mitigation time 86. 5 d, invalid two cases, three cases of recurrence; B group of 16 cases, nine cases of complete remission, partial remission five cases, easing the time 86.5 d, invalid two cases, nine cases of recurrence. Conclusion A, B and two recent remission rate to ease the time required for non-discriminatory, but the group A relapse rate decreased kidney function improved even more significant.