期刊文献+

神经细胞群峰电位的自动定量分析 被引量:2

Automatic quantitative analysis methods for neuronal population spikes
下载PDF
导出
摘要 为了实现具有多个波峰的群峰电位(population spike,PS)幅值的自动分析,设计了一种新的差分算法和海岸线算法,应用于高钾低钙环境下海马神经细胞的诱发群峰电位的计算,并与常规极值搜索法进行比较.结果显示,差分算法的结果与标准值拟合最好,检出的波峰个数也接近人工测量值.海岸线算法的结果与标准值也有良好的相关性.总之,新的差分算法具有精度高、特征点定位准确的优点,可以克服常规极值搜索法的一些不足之处.海岸线算法具有良好的精度,运算速度快,尤其适用于实时检测. A novel differential algorithm and a coastline burst index (CBI) method were designed to automatically analyze the amplitudes of population spikes (PS). By using these two methods, the neuronal evoked response potentials in the hippocampus under high-potassium low-calcium condition were calculated and compared with those of the traditional extremum searching algorithm. Results showed that among these methods, the data of differential algorithm fitted the standard values best. The spike numbers detected by using the differential algorithm agreed with the manual results very well. The data of CBI method also correlated with the standard values nicely. Taken together, these data indicate that the differential method is more precise than the traditional extremum searching algorithm in extracting key points of the recoding potentials, therefore the method is good for automatically analyzing population spike waves under varied neuronal excitatory condition. The CBI method has a proper precise and a high calculation speed, so it is especially suitable for on-line calculations.
作者 光磊 封洲燕
出处 《浙江大学学报(工学版)》 EI CAS CSCD 北大核心 2008年第9期1641-1647,共7页 Journal of Zhejiang University:Engineering Science
基金 国家自然科学基金资助项目(30570585,30770548)
关键词 群峰电位 自动分析 差分算法 海岸线算法 population spike auto-analysis differential algorithm coastline burst index
  • 相关文献

参考文献20

  • 1FENG Z, DURAND D M. Propagation of low calcium non-synaptic induced epileptiform activity to the contralateral hippocampus in vivo [J]. Brain Research, 2005, 1055(1-2):25-35.
  • 2FENG Z, DURAND D M. Low-calcium epileptiform activity in the hippocampus in vivo [J]. Journal of Neurophysiology, 2003, 90 (4): 2253- 2260.
  • 3陈庆梅 ,王绪平 ,张恒义 ,郑筱祥 .群峰电位的定量分析及其在苦参碱研究中的应用(英文)[J].航天医学与医学工程,2004,17(4):303-305. 被引量:6
  • 4BLISS T V, LOMO T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path [J]. The Journal of Physiology, 1973, 232(2): 331 -356.
  • 5THEORET Y, BROWN A, FLEMING SP, et al. Hippocampal field potential: a microcomputer aided comparison of amplitude and integral [J]. Brain Research Bulletin, 1984, 2(5): 589-595.
  • 6FRANSESCHINI R J, BRONZINO J D. A software algorithm for analysis of paired-pulse response change across vigilance states [C] // Proceedings of the IEEE 15th Annual Northeast on Bioengineering. Boston:IEEE, 1989:101 - 102.
  • 7GHOLMIEH G, COURELLIS S, DIMOKA A, et al. An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings [J]. Journal of Neuroscience Methods, 2004, 136(2): 111- 121.
  • 8CHAN C H, SRINIVASAN V, HSIAO M C, et al. Real time hardware neural spike amplitude extraction [C] // Proceedings of the IEEE International Workshop on Biomedical Circuits and Systems. Singapore: IEEE, 2004:20 - 23.
  • 9吴加金,娄艾琳,左和鸣.大鼠海马LTP电位数据的DMA采集及处理的软件设计[J].军事医学科学院院刊,1992,16(4):297-300. 被引量:1
  • 10ANDERSON W W, COLLINGRIDGE G L. The LTP Program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events [J]. Journal of Neuroscience Methods, 2001,108 (1) : 71 -83.

二级参考文献16

  • 1章毓晋.图像工程(上册)--图像分析与处理[M].北京:清华大学出版社,1999..
  • 2章毓晋.图像工程(上册)——图像分析与处理[M].北京:清华大学出版社,1999..
  • 3Chi- Man Pun. Rotation- invariant texture feature for image retrieval [J]. Computer Vision and Image Understanding,2003,89-24 -43.
  • 4Paul Kwan, Keisuke Kameyama, Kazuo Toraichi. On a relaxation - labeling algorithm for real - time contour - based image similarity retrieval[J]. Image and Vision Computing,2003,21: 285 -294.
  • 5Ramchandran K,Vetterli M, Herley C. Wavelets, subband coding, and best bases [A]. Proceedings of the IEEE[C]. 1996,541 - 560.
  • 6Kastrinaki V, Zervakis M, Kalaitzakis K. A survey of video processing techniques for traffic applications [ J ]. Image and VisionComputing, 2003,21: 359-381.
  • 7Peter Bergstrom. Eye -movement -controlled transform image coders [ J ]. Signal Processing: Image Communication, 2003,18:115 -125.
  • 8黄彦猷,生理科学进展,1985年,2卷,154页
  • 9KennethRCastleman 朱志刚译.数字图像处理[M].北京:电子工业出版社,2002.2,390.
  • 10Oliver AP, Hoffer BJ, Wyatt RJ. The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs[J]. Epilepsia, 1977, 8(18): 543-548.

共引文献27

同被引文献31

  • 1封洲燕,光磊,郑晓静,王静,李淑辉.应用线性硅电极阵列检测海马场电位和单细胞动作电位[J].生物化学与生物物理进展,2007,34(4):401-407. 被引量:19
  • 2WOLPAW J, BIRBAUMER N, MCFAR LAND D, et al. Brain–computer interfaces for communication and control[J]. Clinical Neurophysiology, 2002,113(6): 767-791.
  • 3HOCHBERG L, SERRUYA M, FRIEHS G, et al. Neuronal ensemble control of prosthetic devices by a human with tetraplegia[J]. Nature, 2006, 442(7099):164-171.
  • 4LEBEDEV M, NICOLELIS M. Brainmachine interfaces: past, present and future[J]. Trends in Neuroscience, 2006, 29 (9): 536-546.
  • 5SCHWARTZ A, WEBER D, MORAN D,et al. Braineontrolled interfaces: movement restoration with neural prosthetics[J]. Neuron, 2006,52(1): 205-220.
  • 6CHAPIN J, MOXON K , MARKOWITZ R, et al. Realtime control of a robot arm using simultaneously re corded neurons in the motor cortex[J]. Nature Neuroscience,1999, 2(7):664-670.
  • 7王雪文,张志勇.传感器原理及应用[M]. 北京:航空航天大学出版社, 2005:149-150.
  • 8Hauser WA, Beghi E. First seizure definitions and worldwide incidence and mortality [ J ]. Epilepsia, 2008, 49 ( Supplement 1):8-12.
  • 9Eadie MJ. Shortcomings in the current treatment of epilepsy [ J]. Expert Review of Neurotherapeutics, 2012, 12 (12) : 1419 - 1427.
  • 10Laxpati NG, Kasoff WS, Gross RE. Deep brain stimulation for the treatment of epilepsy: circuits, targets, and trials [ J]. Journal of the American Society for Experimental Neurotherapeutics, 2014, 11 (3) : 508 - 526.

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部