摘要
采用自制的窒息模型，利用19只新生大鼠，研究了脑组织中过氧化服质（LPO）和Ca在脑损伤中的作用以及丹参注射液对窒息脑组织中LPO和Ca含量的影响.结果表明：窒息组动物同对照组比较，脑组织LPO和Ca含量明显升高（P＜0.05）;丹参防治组脑组织LPO和Ca含量明显低于窒息组（P＜005），与对照组无显著差异（P＞0.05）。提示：氧自由基、钙超载等因素导致窒息后的脑损伤改变;丹参可降低窒息后脑组织中LPO和Ca含量，因而具有抗窒息性脑损伤的作用.
The role of LPO and Ca in asphyxial brain damage and the offects of Salvia Miltirrhizae (SM) on the contents of LPO and Ca in postasphyxial brain were investigated in 19 newborn rats, The asphyxia model was designed hy ourselves. The results showed that the contents of LPO and Ca in brain of the postasphyxial animals increased obviously as compared with the control group (P<0. 05 ). The contents of LPO and Ca in brain in the SM group obviously decreased as compared with the untreated asphyxia group (P<0. 05), but there was no difference in the control group (P>0. 05). It suggested that oxygen free radicals and calcium overload could play a role in the development of brain damage in postasphyxial animals, and SM might relicve the asphyxial brain from damage by means of decressing the contents of LPO and Ca in the brain.
出处
《泸州医学院学报》
1997年第1期6-8,共3页
Journal of Luzhou Medical College
关键词
新生儿窒息
窒息
过氧化肥质
丹参
钙
Oxygen free radical
Calcium overload
Salvia Miltirrhizae
Asphyxia
Brain damage
