摘要
用急性缺氧模型，研究缺氧后脑组织中过氧化脂质（LPO）和钙离子Ca2+含量的变化.结果表明，缺氧组脑组织中LPO和Ca2+的含量较对照组明显提高（P＜0.05～0.01）.缺氧和再复苏后LPO生成增多，致细胞膜受损，进而对Ca2+的通透性增高，Ca2+内流增加，细胞内Ca2+超载使脑损伤过一步加重。
The change in LPO and Ca2+ caused by acute hypoxic brain injury was investigated by means of the hypoxic model made by the authors. The result showed that there were considerable differences in LPO and Ca2+ contents in brain of the hypoxic group compared with the control group (p<0. 05-0. 01). The increase of LPO and Ca2+ in hypoxic brain tissue resulted in the brain cell membrane damage. The increase of LPO and overload of caclium were the factors which futher damage the brain cell seriously.
出处
《泸州医学院学报》
1997年第1期13-14,共2页
Journal of Luzhou Medical College
关键词
缺氧
脑损伤
脑组织
过氧化脂质
新生儿
Acute hypoxia
Oxygen free radical
Caclium overload
Brain injury
