HLA-DR抗原在肝细胞癌组织中的表达及其意义

Expression of HLA DR in the Tissue of Human Hepatocellular Carcinoma and Its Significance

为了探讨ＨＬＡ－ＤＲ在原发性肝细胞癌中的表达及其意义，本文采用免疫组化ＡＢＣ法检测了ＨＬＡ－ＤＲ在４６例肝细胞癌组织中的表达情况，并分析了其表达水平与肝细胞癌病理分级的关系。结果表明，３９．１％（１８／４６）的肝细胞癌癌细胞表达ＨＬＡ－ＤＲ，而在癌旁非肿瘤细胞中ＨＬＡ－ＤＲ的表达为阴性。其在肝细胞癌中表达的阳性率随肝癌分化程度的下降而降低，在不同病理分级之间的阳性率具有显著性差异（Ｐ＜０．０５）。本研究说明ＨＬＡ－ＤＲ可能作为肝细胞癌发生、发展不同时期的一个标志物，但其在参与抗肿瘤免疫应答中的作用有待进一步探讨。

To probe into the expression of HLA DR in human hepatocellular carcinoma (HCC) and its significance, the expression of HLA DR in 46 HCC was detected with immunohistochemical ABC method, and the relationship between HLA DR and the pathological degree of HCC was analyzed. The results showed that 18 cases among 46 cases (39.1%) of HCC expressed HLA DR, while normal liver cells immediately adjacent to HCC were HLA DR negative. The positive rate of the expression of HLA DR in HCC was significantly variable among different pathological degrees(P<0.05). Our research indicates that HLA DR might be regarded as a marker of the genesis and development of HCC, but its role in anti tumor immunological response should be studied further.