摘要
目的探讨血清淀粉样蛋白A(SAA)、白细胞介素(IL)-18与2型糖尿病(他DM)及其合并大血管病变的关系。方法将65例T2DM患者(T2DM组)分为T2DM无并发症组(34例)和T2DM合并大血管病变组(31例),另选取30例健康体检者作为对照组。采用ELISA法测定SAA和IL-18水平,并进行相关性分析。结果T2DM组患者SAA、IL-18水平[(3.09±0.96)mg/L和(98.8±36.4)ng/L]显著高于对照组[(1.06±0.45)mg/L和(58.9±15.6)ng/L],差异均有统计学意义(P〈0.05),T2DM合并大血管病变组患者SAA、IL-18水平[(6.34±1.52)mg/L和(141.2±48.3)ng/L]与T2DM无并发症组患者[(2.65±0.39)mg/L,(80.2±20.1)ng/L]比较差异均有统计学意义(P〈0.05)。另外相关分析显示:SAA与IL-18呈正相关(r=0.615,P〈o.05),SAA、IL-18分别与空腹血糖呈正相关(r=0.312、0.428,P〈0.05)。结论SAA、IL-18在T2DM及合并大血管病变患者中明显升高,在其发生和发展中具有重要的临床意义,可能是T2DM合并大血管病变的重要危险因素。
Objective To investigate the serum amyloid A (SAA) and interleukin-18(IL-18) concentration in the pathogenesis of type 2 diabetes mellitus (T2DM) and its macrovascular complications. and study the relation between them. Methods ELISA was used to assay serum SAA and IL-18 levels in 65 T2DM patients (including 31 cases with maerovascular complications ) and 30 healthy controls. Results Serum SAA and IL-18 levels [ (3.09± 0.96)mg/L, (98.8 ±36.4 )ng/L]were significantly elevated in patients with T2DM as compared with those in control subjects [ ( 1.06 ± 0.45)mg/L. (58.9 ±5.6)ng/L] (P 〈 0.05). There was significant difference of SAA and IL-18 levels between T2DM patients with [ ( 6.34 ± 1.52) mg/L, ( 141.2 ± 48.3 )ng/L ] and without maerovascukar complications [ ( 2.65 ±0.39 )mg/L, ( 80.2 ± 20.1 )ng/L](P 〈 0.05 ).Univariate linear regression analysis showed significant positive correlations between serum [L-18 with SAA (r = 0.615, P〈 0.05), SAA, IL-18 and fasting blood glucose (FBG) had mutual positive correlations (r = 0.312, 0.428, P 〈 0.05, respectively). Conclusions In patients with T2DM. serum SAA and IL-18 concentration is greater than in non-diabetic subjects. SAA and IL-18 play important roles in the initiation and development of T2DM. The study suggests that SAA and IL-18 might be an important independent risk factor.
出处
《中国医师进修杂志(内科版)》
2008年第10期37-39,共3页
Chinese Journal of Postgraduates of Medicine