期刊文献+

姜黄素对前列腺癌PC-3M细胞抗侵袭作用的研究 被引量:1

下载PDF
导出
摘要 为探讨姜黄素对前列腺癌PC-3M细胞抗侵袭作用,将0~40μmol/L姜黄素分别处理PC-3M细胞24h后,Westernblot法检测MMP-2和TIMP-2蛋白表达,免疫组化SP法检测细胞内NF-κB蛋白的表达水平。结果表明,姜黄素可下调MMP-2和上调TMP-2的表达,抑制NF-κB的表达。结论:姜黄素通过下调MMP-2和上调TIMP-2的蛋白表达发挥抗侵袭作用,抑制NF-κB的表达可能是抗侵袭作用的机制之一。
机构地区
出处 《沈阳部队医药》 2008年第5期312-314,共3页
基金 吉林省科技厅资助课题(编号963001-2)
  • 相关文献

参考文献2

  • 1高庆,吴秉铨.基质金属蛋白酶与肿瘤侵袭和转移[J].中华病理学杂志,1998,27(2):155-156. 被引量:40
  • 2Paul F. Lindholm,Jeffrey Bub,Sushma Kaul,Vinod B. Shidham,André Kajdacsy-Balla. The role of constitutive NF-κB activity in PC-3 human prostate cancer cell invasive behavior[J] 2000,Clinical and Experimental Metastasis(6):471~479

共引文献39

同被引文献15

  • 1吴晓健,吴凯南.姜黄素对人乳腺癌MCF-7细胞抗增殖作用的研究[J].第三军医大学学报,2006,28(18):1870-1872. 被引量:18
  • 2刘海艳,温玉库.姜黄素对人卵巢癌细胞株HO-8910增殖和凋亡的影响[J].医学理论与实践,2007,20(5):501-503. 被引量:4
  • 3张竹强,岳秀兰,曹虹然,白雪峰.散发性卵巢癌中BRCA1基因突变的研究[J].包头医学院学报,2007,23(4):339-342. 被引量:1
  • 4Danica L Rowe, Tuba Ozbay, Ruth M O'Regan, et al. Modulation of the BRCA1 protein and induction of apoptosis in triple negative breast cancer cell lines by the polyphenolic compound curcumin [ J ]. Breast Cancer,2009,3 : 61 - 75.
  • 5Randrianarison V, Marot D, Foray N, et al. BRCA1 carries tumor suppressor activity distinct from that of p53 and p21 [ J]. Cancer Gene Ther, 2001,8 ( 10 ) :759 - 770.
  • 6Horiuchi A, Wang C, Kikuchi N,et al. BRCA1 Expression is an important biomarker for chemosensitivity: suppression of BRCA1 increases the apoptosis via Up - regulation of p53 and p21 during cisplatin treatment in ovarian cancer ceils [ J ]. Biomark Insights, 2007, 1:49 -59.
  • 7Leunen K, Cadron I, Van Gorp T, et al. Does paclitaxel - carbo- platin chemotherapy in a dose - dense regimen enhance survival of BRCA - related ovarian cancer patients[ J ] ? Int J Gynecol Canc- er, 2009,19(9) :1501 - 1504 .
  • 8Quinn JE, James CR, Stewart GE,et al. BRCA1 mRNA expres- sion levels predict for overall survival in ovarian cancer after chemotherapy [ J ]. Clin Cancer Res, 2007, 13 ( 24 ) : 7413 - 7420.
  • 9Weir NM, Selvendiran K, Kutala VK. Curcumin induces G2/M arrest and apoptosis in cisplatin - resistant human ovarian cancer ceils by modulating Akt and p38 MAPK [ J ]. Cancer Biol Ther, 2007, 6(2) :178 - 184.
  • 10Somasundaram K, Zhang H, Zeng YX, et al. Arrest of the cell cy- cle by the tumour - suppressor BRCA1 requires the CDK - inhibi- tor p21WAF1/CiP1 [ J]. Nature, 1997,389 (6647) : 187 - 190.

引证文献1

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部