汉、蒙、维、畲四民族DR4亚型的研究

THE DISTRIBUTION OF DR4 SUBSETS IN HAN,MONGOLIAN,UIGHURIAN AND SHEZU IN CHINA

为了解不同民族的ＤＲ４亚型，对９２例河北汉族、８０例西安汉族、５０例蒙古族、９２例新疆维族、９８例福建畲族进行了ＤＲ４亚型的比较研究。发现ＤＲＢ１＊０４０１等位基因频率在我国由北向南呈递减趋势，从蒙古族的１４．０％降至湖南汉族的１．５％。新疆维族存在着较高比例的白人基因ＤＲＢ１＊０４０４（６．６％）和ＤＲＢ１＊０４０１（５．５％）。福建畲族ＤＲＢ１＊０４０５（８．２％）、ＤＲＢ１＊０４０６（８．２％）的频率均较高而与河北汉族相近似。ＨＬＡ－ＤＲ４亚型的分布揭示出祖先民族迁移与融合的历史。

HLADR4 subsets of 92 Hebei Hans,80 Xi’an Hans,50 InnerMongolinans,92 Uighurians and 98 Fujian Shezu were determined by using PCR/SSO. Frequency of DRB1*0401 decreases southwards from InnerMongolians(14.0%) to Hunan Hans(1.5%).The Uighurians have higher frequencies of Caucasian genes such as DRB1*0404(6.6%) and DRB1*0401(5.5%). Frequencies of DRB1*0405 (8.2%) and 0406(8.2%) were higher in Fujian Shezu which were similar to these of northern Hans.The distribution of HLA DR4 subsets frequencies suggests the migration and mutual amalgamation of our ancestors.This paper also discussed the relationship between the four nationalities.