大鼠海马CA_1区神经元对电刺激下丘脑腹内侧核的反应

Responses of Hippocampal CA1 Neurons to Electrical Stimulation of Ventromedial Hypothalamic Nucleus in the Rat

以细胞外玻璃微电极技术记录海马ＣＡ１区神经元的单位放电，观察电刺激下丘脑腹内侧核（ＶＭＨ）时ＣＡ１区神经元的反应。结果发现，刺激ＶＭＨ时，可在６７．８％的ＣＡ１神经元记录到场电位，其峰潜伏期为（１７．９±８．４）ｍｓ，（范围：１０～３５ｍｓ），时程（３０．９±１２．３）ｍｓ，（范围：１５～５５ｍｓ）。约７０％的ＣＡ１神经元（２４／３４）的自发放电频率在刺激ＶＭＨ后发生变化，表现为兴奋，兴奋后抑制及兴奋－抑制－兴奋序列和抑制反应，其余３０％（１０／３４）在刺激前后自发放电频率变化不明显。结果表明，兴奋ＶＭＨ可影响ＣＡ１神经元的电活动，而且影响方式多种多样。

e conducted experiments in 11 rats. Unit discharges of CA1 neurons were recorded by glass microelectrode extracellularly. VMH was stimulated with bipolar electrode. The electrical activity of neurons in CA1 and their responses to VMH stimulation were observed. The main results were as follows: After VMH stimulation, 67.8% of CA1 neurons showed field potential responses. The peak latency of the evoked field potential responses was (17.9±8.4)ms (range:1035 ms) and their time course (30±12.3)ms (range:1555 ms). In 70.6% of CA1 units tested (24/34),the frequencies of spontaneous activity were changed. The patterns of change included excitation, excitationinhibition or excitation inhibitionexcitation sequences, inhibition,and inhibitionexcitation. These results suggested that VMH should be able to influence CA1 neurons and the patterns of the influences might be various.