血浆前列腺素E_2测定对胰腺癌的诊断价值

Diagnostic Value of Prostaglandin E2 for Pancreatic Cancer

为探讨胰腺癌患者血浆中前列腺素Ｅ２（ｐｒｏｓｔａｇｌａｎｄｉｎＥ２，ＰＧＥ２）的含量及其意义，实验用放射免疫分析法测定１９例胰腺癌患者，６例胰腺良性疾病患者，５例良性黄疸患者，８例健康成人的外周静脉血浆中ＰＧＥ２水平。结果：胰腺癌患者ＰＧＥ２水平明显高于健康对照组，且术前术后相比呈显著性差异；良性胰腺疾病患者及良性黄疸患者血浆ＰＧＥ２水平与正常对照组相比均无显著差异。而与胰腺癌患者血浆ＰＧＥ２水平相比则具有显著差异。结论：胰腺癌与ＰＧＥ２关系密切，胰腺癌组织能产生ＰＧＥ２并释放入血；ＰＧＥ２水平测定对胰腺癌的诊断及鉴别诊断有应用价值。

Prostaglandlins, especially prostaglandin E2(PGE2) is closely related to the malignant tumor.But none has detected the plasma concentration of PGE2 among the patients with pancreatic cancer domestically. Methods: We collected the plasma samples in 19 patients with pancreatic cancer, 6 sudjects with benign stenosis or cholangiolithiasis, and 8 healthy people as a control.The PGE2 concentration was examined by radioimmunoessay. Results: The plasma level of PGE2 for pancreatic cancer patients was significantly higher than that of the healthy controls and that of the group with benign diseases. There was no significant difference in plasma level of PGE2 between the group with benign diseases and the healthy controls. Conclusions: PGE2 is colsely related to pancreatic cancer. The tissue of pancreatic cancer may produce PGE2 and release it into blood. The detection of PGE2 is valuable for both diagnosis and differential diagnosis of pancreatic cancer.