哮喘患儿血浆降钙素基因相关肽水平的变化

Changes of Plasma Calcitonin GeneRelated Peptide in Asthmatic Children

为探讨降钙素基因相关肽（ＣＧＲＰ）与哮喘的关系，用放射免疫分析法，动态观察了３８例哮喘急性发作期及临床缓解期患儿血浆ＣＧＲＰ含量变化。结果：哮喘急性发作期血浆ＣＧＲＰ含量较其临床缓解期、轻型支气管肺炎组及健康组均显著降低（Ｐ＜０．０１）；重度哮喘急性发作期血浆ＣＧＲＰ含量显著低于轻度哮喘（Ｐ＜０．０１）；随哮喘的缓解，血浆ＣＧＲＰ含量随之上升并接近健康组水平；哮喘临床缓解期、轻型支气管肺炎及正常对照组间血浆ＣＧＲＰ含量无显著差异（Ｐ＞０．０５）。结论：血浆ＣＧＲＰ含量的降低可能对哮喘的发作有一定的促进作用，而增高则可能有利于哮喘的缓解。

o explore the relationship between the Calcitonin generelated peptide (CGRP) and asthma in children, we measured the levels of plasma CGRP in 38 asthmatic children by Redioimmunoassay at the stage of acute attack and clinical remission. The results: the level of plasma CGRP in asthmatic children was significantly lower (P<0.01) at the stage of acute attack than that of clinical remission, ofpatients with bronchopneumonia, and of normal control; the level of plasma CGRP in severe asthma decreased significantly (P<0.01) than that in mild asthma; there was no significant difference(P>0.05) among patients at the stage of remission in asthma, in bronchopneumonia, and normal control. We suggested that the decrease of plasms CGRP might play an important role in the pathosgenesis of asthma.