抗炎和免疫调节治疗在心力衰竭中的应用

Anti-inflammatory and Immunomodulation Therapy Applied in Heart Failure Treatment

几十年来,人们已认识到充血性心力衰竭(CHF)的机制是伴有神经内分泌激活的血流动力学的改变。目前,越来越多的证据表明免疫系统的激活和持续的炎症反应(尤其是炎症细胞因子网络的失衡)在CHF的发生发展中发挥重要作用。据此,CHF可被看做是免疫激活和循环血中前炎症因子和抗炎因子增加引起的炎症反应的结果。抗炎和免疫调节治疗成为CHF治疗的新方向。

Until some decades ago chronic heart failure （CHF） was considered a haemodynamic disorder with neurohormonal activation. At present , a growing body of evidence suggests that immune activation and persistent inflammation （ especially the imbalance in inflammatory cytokine network ）play an important role in the development and progression of CHF. CHF may be considered a state of immune activation and persistent inflammation expressed by increased circulating levels of pro- and anti-inflammatory cytokines. Anti-inflammatory and immunomodulafion therapy have now become potential directions for the future of CHF treatment.