糖尿病急性心肌梗死患者心力衰竭与cTnI浓度关系

The Relationship of Level of Cardiac Troponin I and Heart Failure in Acute Myocardial Infarction Concomitant Diabetes Mellitus

目的:探讨糖尿病急性心肌梗死(AMI)患者引起心力衰竭与肌钙蛋白I(cTnI)浓度的关系。方法:AMI心力衰竭74例,其中糖尿病心力衰竭组(A组,n=34),非糖尿病心力衰竭组(B组,n=40),于胸痛发作后3、6、9、12、15h抽静脉血3mL,健康对照组(C组,n=60),抽空腹静脉血3mL,采用化学发光免疫分析法(CLIA)定量检测cTnI。结果:A组峰值cTnI(11.94±8.16)μg/L,B组峰值cTnI(11.14±7.99)μg/L,与C组比较有显著差异(P<0.01)。AMI心力衰竭患者cTnI于胸痛3h后随时间增加而逐步增高,于12h左右达峰值。当cTnI浓度达到12μg/L左右时,可出现心力衰竭。结论:当cTnI浓度达到12μg/L左右时,可能是糖尿病AMI心力衰竭的阈值。cTnI浓度的测定对糖尿病AMI心力衰竭诊断及判断心肌梗死程度有重大意义。

Objective： To explore＇the relationship of cardiac troponin Ⅰ （cTnI）level and heart failure in acute myocardial infarction （AMI） concomitant diabetes mellitus （DM）. Methods： 74 AMI patients with heart failure into two groups：34 with DM （Group A） and 40 with non-diabetes mellitus（Group B） compared with 60 normal person （Group C）. Use the chemiluminescence＇s immunoassay（CLIA）approach ration to check the serum cTnI at 3,6,9, 12,15 hours after the chest aches occured. Results： The CTnI level was creasing after chest ache occurred and arrived the top at 12 hs and higher than Group C, especially in Group A. It occured heart failure after the cTnI level arrised to 12 μg/L. Conclusion： It may be a threshold of heart failure in AMI with DM when the cTnI level arrised to 12 μg/L. There is a great significance to check cTnI in AMI with DM patients.