乙酰谷酰胺治疗高血压性基底节区脑梗死的临床研究

The Clinical Study of Acetylglutamide Treatment in Patient with Hypertension and Cerebral Infarction in Basal Ganglia

目的:观察在常规治疗基础上加用乙酰谷酰胺对高血压性基底节区脑梗死的治疗效果。方法:63例高血压性基底节区脑梗死病人,随机分成治疗组30例和对照组33例。对照组采用常规治疗方法,治疗组在对照组治疗的基础上加用乙酰谷酰胺,治疗14d;观察改良的斯堪的纳维亚卒中量表(SSS)评分和修订的Rankin量表(RS)分级的变化。结果:治疗14d、21d时SSS评分治疗组比对照组低(P<0.05)。起病后60d时RS分级两组间有差异(P<0.05)。结论:应用乙酰谷酰胺能有效地促进脑梗死患者的神经功能恢复。

Objective： To observe the therapeutic effects of acetylglutamide on the base of conventional therapy on the patients with high blood pressure and cerebral infarction in basal ganglia. Methods： 63 patients with hypertension and cerebral infarction in basal ganglia were divided into acetylglutamide treated group and control group randomly, and the two groups contained 30 patients and 33 patients respectively. The control group was treated with conventional therapy, while the aeetylglutamide treated group was treated 14 days with aeetylglutamide on the base of conventional therapy. The improved scandinavian stroke scale （SSS） and the revised rankin scale （RS） were observed. Results： After 14 and 21 days treatment, the score values of SSS of the acetylglutamide treated group was lower than that of the control group（P 〈 0.05）. After 60 days of the onset of the disease, the degrees of RS in both groups were statistically significant differences （P 〈 0.05）. Conclusions： Acetylglutamide can effectively promote the recovery of nervous function in the patients with cerebral infarction.